Egan TJ - Search Results

1

Antischistosomal Activity of Pyrido[1,2-a]benzimidazole Derivatives and Correlation with Inhibition of β-Hematin Formation.

Okombo J, Singh K, Mayoka G, Ndubi F, Barnard L, Njogu PM, Njoroge M, Gibhard L, Brunschwig C, Vargas M, Keiser J, Egan TJ, Chibale K. Okombo J, et al. Among authors: egan tj. ACS Infect Dis. 2017 Jun 9;3(6):411-420. doi: 10.1021/acsinfecdis.6b00205. Epub 2017 May 3. ACS Infect Dis. 2017. PMID: 28440625

2

A colorimetric high-throughput beta-hematin inhibition screening assay for use in the search for antimalarial compounds.

Ncokazi KK, Egan TJ. Ncokazi KK, et al. Among authors: egan tj. Anal Biochem. 2005 Mar 15;338(2):306-19. doi: 10.1016/j.ab.2004.11.022. Anal Biochem. 2005. PMID: 15745752

3

Haemozoin formation.

Egan TJ. Egan TJ. Mol Biochem Parasitol. 2008 Feb;157(2):127-36. doi: 10.1016/j.molbiopara.2007.11.005. Epub 2007 Nov 17. Mol Biochem Parasitol. 2008. PMID: 18083247 Review.

4

Recent advances in understanding the mechanism of hemozoin (malaria pigment) formation.

Egan TJ. Egan TJ. J Inorg Biochem. 2008 May-Jun;102(5-6):1288-99. doi: 10.1016/j.jinorgbio.2007.12.004. Epub 2007 Dec 23. J Inorg Biochem. 2008. PMID: 18226838 Review.

5

Reversed chloroquines based on the 3,4-dihydropyrimidin-2(1H)-one scaffold: synthesis and evaluation for antimalarial, beta-haematin inhibition, and cytotoxic activity.

October N, Watermeyer ND, Yardley V, Egan TJ, Ncokazi K, Chibale K. October N, et al. Among authors: egan tj. ChemMedChem. 2008 Nov;3(11):1649-53. doi: 10.1002/cmdc.200800172. ChemMedChem. 2008. PMID: 18846586 No abstract available.

6

Antiplasmodial, beta-haematin inhibition, antitrypanosomal and cytotoxic activity in vitro of novel 4-aminoquinoline 2-imidazolines.

Musonda CC, Yardley V, de Souza RC, Ncokazi K, Egan TJ, Chibale K. Musonda CC, et al. Among authors: egan tj. Org Biomol Chem. 2008 Dec 7;6(23):4446-51. doi: 10.1039/b813007h. Epub 2008 Oct 24. Org Biomol Chem. 2008. PMID: 19005606

7

Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds.

Guantai EM, Ncokazi K, Egan TJ, Gut J, Rosenthal PJ, Smith PJ, Chibale K. Guantai EM, et al. Among authors: egan tj. Bioorg Med Chem. 2010 Dec 1;18(23):8243-56. doi: 10.1016/j.bmc.2010.10.009. Epub 2010 Oct 31. Bioorg Med Chem. 2010. PMID: 21044845

8

Linear free energy relationships predict coordination and π-stacking interactions of small molecules with ferriprotoporphyrin IX.

Kuter D, Chibale K, Egan TJ. Kuter D, et al. Among authors: egan tj. J Inorg Biochem. 2011 May;105(5):684-92. doi: 10.1016/j.jinorgbio.2011.02.008. Epub 2011 Feb 26. J Inorg Biochem. 2011. PMID: 21450272

9

Enone- and chalcone-chloroquinoline hybrid analogues: in silico guided design, synthesis, antiplasmodial activity, in vitro metabolism, and mechanistic studies.

Guantai EM, Ncokazi K, Egan TJ, Gut J, Rosenthal PJ, Bhampidipati R, Kopinathan A, Smith PJ, Chibale K. Guantai EM, et al. Among authors: egan tj. J Med Chem. 2011 May 26;54(10):3637-49. doi: 10.1021/jm200149e. Epub 2011 May 5. J Med Chem. 2011. PMID: 21500839 Free PMC article.

10

Effects of highly active novel artemisinin-chloroquinoline hybrid compounds on β-hematin formation, parasite morphology and endocytosis in Plasmodium falciparum.

Feng TS, Guantai EM, Nell M, van Rensburg CE, Ncokazi K, Egan TJ, Hoppe HC, Chibale K. Feng TS, et al. Among authors: egan tj. Biochem Pharmacol. 2011 Aug 1;82(3):236-47. doi: 10.1016/j.bcp.2011.04.018. Epub 2011 May 8. Biochem Pharmacol. 2011. PMID: 21596024

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