Njoroge M - Search Results

1

Antischistosomal Activity of Pyrido[1,2-a]benzimidazole Derivatives and Correlation with Inhibition of β-Hematin Formation.

Okombo J, Singh K, Mayoka G, Ndubi F, Barnard L, Njogu PM, Njoroge M, Gibhard L, Brunschwig C, Vargas M, Keiser J, Egan TJ, Chibale K. Okombo J, et al. Among authors: njoroge m. ACS Infect Dis. 2017 Jun 9;3(6):411-420. doi: 10.1021/acsinfecdis.6b00205. Epub 2017 May 3. ACS Infect Dis. 2017. PMID: 28440625

2

Comparison of electrospray ionisation, atmospheric pressure chemical ionisation and atmospheric pressure photoionisation for the identification of metabolites from labile artemisinin-based anti-malarial drugs using a QTRAP® mass spectrometer.

Louw S, Njoroge M, Chigorimbo-Murefu N, Chibale K. Louw S, et al. Among authors: njoroge m. Rapid Commun Mass Spectrom. 2012 Oct 30;26(20):2431-42. doi: 10.1002/rcm.6359. Rapid Commun Mass Spectrom. 2012. PMID: 22976210

3

Biotransformation and biocatalysis: roles and applications in the discovery of antimalarials.

Chigorimbo-Murefu NT, Njoroge M, Nzila A, Louw S, Masimirembwa C, Chibale K. Chigorimbo-Murefu NT, et al. Among authors: njoroge m. Future Med Chem. 2012 Dec;4(18):2325-36. doi: 10.4155/fmc.12.173. Future Med Chem. 2012. PMID: 23234554 Review.

4

Tetrazole-based deoxyamodiaquines: synthesis, ADME/PK profiling and pharmacological evaluation as potential antimalarial agents.

Tukulula M, Njoroge M, Mugumbate GC, Gut J, Rosenthal PJ, Barteau S, Streckfuss J, Heudi O, Kameni-Tcheudji J, Chibale K. Tukulula M, et al. Among authors: njoroge m. Bioorg Med Chem. 2013 Sep 1;21(17):4904-13. doi: 10.1016/j.bmc.2013.06.067. Epub 2013 Jul 11. Bioorg Med Chem. 2013. PMID: 23896611

5

Drug metabolite generation using a laboratory evolved NADPH independent cytochrome P450: application of in vitro and in silico approaches.

Chigorimbo-Murefu NT, Njoroge M, Louw S, Mugumbate G, Chibale K. Chigorimbo-Murefu NT, et al. Among authors: njoroge m. Drug Metab Lett. 2013 Mar;7(1):68-77. doi: 10.2174/18723128112069990014. Drug Metab Lett. 2013. PMID: 23957950

6

Synthesis and biological evaluation of 2-aminothiazole derivatives as antimycobacterial and antiplasmodial agents.

Mjambili F, Njoroge M, Naran K, De Kock C, Smith PJ, Mizrahi V, Warner D, Chibale K. Mjambili F, et al. Among authors: njoroge m. Bioorg Med Chem Lett. 2014 Jan 15;24(2):560-4. doi: 10.1016/j.bmcl.2013.12.022. Epub 2013 Dec 12. Bioorg Med Chem Lett. 2014. PMID: 24373723

7

Pharmacokinetic evaluation of lisinopril-tryptophan, a novel C-domain ACE inhibitor.

Denti P, Sharp SK, Kröger WL, Schwager SL, Mahajan A, Njoroge M, Gibhard L, Smit I, Chibale K, Wiesner L, Sturrock ED, Davies NH. Denti P, et al. Among authors: njoroge m. Eur J Pharm Sci. 2014 Jun 2;56:113-9. doi: 10.1016/j.ejps.2014.01.012. Epub 2014 Feb 20. Eur J Pharm Sci. 2014. PMID: 24561703

8

Synthesis and in vitro and in vivo pharmacological evaluation of new 4-aminoquinoline-based compounds.

Tukulula M, Njoroge M, Abay ET, Mugumbate GC, Wiesner L, Taylor D, Gibhard L, Norman J, Swart KJ, Gut J, Rosenthal PJ, Barteau S, Streckfuss J, Kameni-Tcheudji J, Chibale K. Tukulula M, et al. Among authors: njoroge m. ACS Med Chem Lett. 2013 Oct 1;4(12):1198-202. doi: 10.1021/ml400311r. eCollection 2013 Dec 12. ACS Med Chem Lett. 2013. PMID: 24900630 Free PMC article.

9

Recent approaches to chemical discovery and development against malaria and the neglected tropical diseases human African trypanosomiasis and schistosomiasis.

Njoroge M, Njuguna NM, Mutai P, Ongarora DS, Smith PW, Chibale K. Njoroge M, et al. Chem Rev. 2014 Nov 26;114(22):11138-63. doi: 10.1021/cr500098f. Epub 2014 Jul 11. Chem Rev. 2014. PMID: 25014712 Review. No abstract available.

10

Synthesis and structure-activity-relationship studies of thiazolidinediones as antiplasmodial inhibitors of the Plasmodium falciparum cysteine protease falcipain-2.

Sharma RK, Younis Y, Mugumbate G, Njoroge M, Gut J, Rosenthal PJ, Chibale K. Sharma RK, et al. Among authors: njoroge m. Eur J Med Chem. 2015 Jan 27;90:507-18. doi: 10.1016/j.ejmech.2014.11.061. Epub 2014 Dec 2. Eur J Med Chem. 2015. PMID: 25486422

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