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Page 1
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target.
Istvan ES, Guerra F, Abraham M, Huang KS, Rocamora F, Zhao H, Xu L, Pasaje C, Kumpornsin K, Luth MR, Cui H, Yang T, Palomo Diaz S, Gomez-Lorenzo MG, Qahash T, Mittal N, Ottilie S, Niles J, Lee MCS, Llinas M, Kato N, Okombo J, Fidock DA, Schimmel P, Gamo FJ, Goldberg DE, Winzeler EA. Istvan ES, et al. Among authors: okombo j. Sci Transl Med. 2023 Mar 8;15(686):eadc9249. doi: 10.1126/scitranslmed.adc9249. Epub 2023 Mar 8. Sci Transl Med. 2023. PMID: 36888694 Free PMC article.
Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology.
Hagenah LM, Dhingra SK, Small-Saunders JL, Qahash T, Willems A, Schindler KA, Rangel GW, Gil-Iturbe E, Kim J, Akhundova E, Yeo T, Okombo J, Mancia F, Quick M, Roepe PD, Llinás M, Fidock DA. Hagenah LM, et al. Among authors: okombo j. mBio. 2024 Jan 16;15(1):e0183223. doi: 10.1128/mbio.01832-23. Epub 2023 Dec 7. mBio. 2024. PMID: 38059639 Free PMC article.
Chloroquine-containing compounds: a patent review (2010 - 2014).
Njaria PM, Okombo J, Njuguna NM, Chibale K. Njaria PM, et al. Among authors: okombo j. Expert Opin Ther Pat. 2015;25(9):1003-24. doi: 10.1517/13543776.2015.1050791. Epub 2015 Jun 1. Expert Opin Ther Pat. 2015. PMID: 26013494 Free PMC article. Review.
Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.
Singh K, Okombo J, Brunschwig C, Ndubi F, Barnard L, Wilkinson C, Njogu PM, Njoroge M, Laing L, Machado M, Prudêncio M, Reader J, Botha M, Nondaba S, Birkholtz LM, Lauterbach S, Churchyard A, Coetzer TL, Burrows JN, Yeates C, Denti P, Wiesner L, Egan TJ, Wittlin S, Chibale K. Singh K, et al. Among authors: okombo j. J Med Chem. 2017 Feb 23;60(4):1432-1448. doi: 10.1021/acs.jmedchem.6b01641. Epub 2017 Feb 7. J Med Chem. 2017. PMID: 28094524
57 results