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Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis.
Ramdzan YM, Trubetskov MM, Ormsby AR, Newcombe EA, Sui X, Tobin MJ, Bongiovanni MN, Gras SL, Dewson G, Miller JML, Finkbeiner S, Moily NS, Niclis J, Parish CL, Purcell AW, Baker MJ, Wilce JA, Waris S, Stojanovski D, Böcking T, Ang CS, Ascher DB, Reid GE, Hatters DM. Ramdzan YM, et al. Among authors: hatters dm. Cell Rep. 2017 May 2;19(5):919-927. doi: 10.1016/j.celrep.2017.04.029. Cell Rep. 2017. PMID: 28467905 Free article.
Identifying polyglutamine protein species in situ that best predict neurodegeneration.
Miller J, Arrasate M, Brooks E, Libeu CP, Legleiter J, Hatters D, Curtis J, Cheung K, Krishnan P, Mitra S, Widjaja K, Shaby BA, Lotz GP, Newhouse Y, Mitchell EJ, Osmand A, Gray M, Thulasiramin V, Saudou F, Segal M, Yang XW, Masliah E, Thompson LM, Muchowski PJ, Weisgraber KH, Finkbeiner S. Miller J, et al. Nat Chem Biol. 2011 Oct 30;7(12):925-34. doi: 10.1038/nchembio.694. Nat Chem Biol. 2011. PMID: 22037470 Free PMC article.
Disease-associated polyglutamine stretches in monomeric huntingtin adopt a compact structure.
Peters-Libeu C, Miller J, Rutenber E, Newhouse Y, Krishnan P, Cheung K, Hatters D, Brooks E, Widjaja K, Tran T, Mitra S, Arrasate M, Mosquera LA, Taylor D, Weisgraber KH, Finkbeiner S. Peters-Libeu C, et al. J Mol Biol. 2012 Aug 24;421(4-5):587-600. doi: 10.1016/j.jmb.2012.01.034. Epub 2012 Jan 28. J Mol Biol. 2012. PMID: 22306738 Free PMC article.
84 results