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The importance of functional tests to assess the effect of a new CFTR variant when genotype-phenotype correlation is not possible.
Hinzpeter A, Reboul MP, Callebaut I, Zordan C, Costes B, Guichoux J, Iron A, Lacombe D, Martin N, Arveiler B, Fanen P, Fergelot P, Girodon E. Hinzpeter A, et al. Among authors: callebaut i. Clin Case Rep. 2017 Mar 30;5(5):658-663. doi: 10.1002/ccr3.760. eCollection 2017 May. Clin Case Rep. 2017. PMID: 28469871 Free PMC article.
Unsolved severe chronic rhinosinusitis elucidated by extensive CFTR genotyping.
Degrugillier F, Simon S, Aissat A, Remus N, Mekki C, Decrouy X, Hatton A, Hinzpeter A, Hoffmann B, Sermet-Gaudelus I, Callebaut I, Fanen P, Prulière-Escabasse V. Degrugillier F, et al. Among authors: callebaut i. Clin Case Rep. 2019 Sep 27;7(11):2128-2134. doi: 10.1002/ccr3.2443. eCollection 2019 Nov. Clin Case Rep. 2019. PMID: 31788264 Free PMC article.
Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity.
Froux L, Elbahnsi A, Boucherle B, Billet A, Baatallah N, Hoffmann B, Alliot J, Zelli R, Zeinyeh W, Haudecoeur R, Chevalier B, Fortuné A, Mirval S, Simard C, Lehn P, Mornon JP, Hinzpeter A, Becq F, Callebaut I, Décout JL. Froux L, et al. Among authors: callebaut i. Eur J Med Chem. 2020 Mar 15;190:112116. doi: 10.1016/j.ejmech.2020.112116. Epub 2020 Feb 9. Eur J Med Chem. 2020. PMID: 32078860
New insights into structure and function of bis-phosphinic acid derivatives and implications for CFTR modulation.
Bitam S, Elbahnsi A, Creste G, Pranke I, Chevalier B, Berhal F, Hoffmann B, Servel N, Baatalah N, Tondelier D, Hatton A, Moquereau C, Faria Da Cunha M, Pastor A, Lepissier A, Hinzpeter A, Mornon JP, Prestat G, Edelman A, Callebaut I, Gravier-Pelletier C, Sermet-Gaudelus I. Bitam S, et al. Among authors: callebaut i. Sci Rep. 2021 Mar 25;11(1):6842. doi: 10.1038/s41598-021-83240-x. Sci Rep. 2021. PMID: 33767236 Free PMC article.
Author Correction: New insights into structure and function of bis-phosphinic acid derivatives and implications for CFTR modulation.
Bitam S, Elbahnsi A, Creste G, Pranke I, Chevalier B, Berhal F, Hoffmann B, Servel N, Baatalah N, Tondelier D, Hatton A, Moquereau C, Faria Da Cunha M, Pastor A, Lepissier A, Hinzpeter A, Mornon JP, Prestat G, Edelman A, Callebaut I, Gravier-Pelletier C, Sermet-Gaudelus I. Bitam S, et al. Among authors: callebaut i. Sci Rep. 2021 Sep 15;11(1):18709. doi: 10.1038/s41598-021-98301-4. Sci Rep. 2021. PMID: 34526640 Free PMC article. No abstract available.
Structure-Based Understanding of ABCA3 Variants.
Onnée M, Fanen P, Callebaut I, de Becdelièvre A. Onnée M, et al. Among authors: callebaut i. Int J Mol Sci. 2021 Sep 24;22(19):10282. doi: 10.3390/ijms221910282. Int J Mol Sci. 2021. PMID: 34638622 Free PMC article.
Pharmacological chaperones improve intra-domain stability and inter-domain assembly via distinct binding sites to rescue misfolded CFTR.
Baatallah N, Elbahnsi A, Mornon JP, Chevalier B, Pranke I, Servel N, Zelli R, Décout JL, Edelman A, Sermet-Gaudelus I, Callebaut I, Hinzpeter A. Baatallah N, et al. Among authors: callebaut i. Cell Mol Life Sci. 2021 Dec;78(23):7813-7829. doi: 10.1007/s00018-021-03994-5. Epub 2021 Oct 29. Cell Mol Life Sci. 2021. PMID: 34714360 Free PMC article.
307 results