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Page 1
Elucidating the Phase I metabolism of psilocin in vitro.
Chen J, Wang Z, Yong CY, Goh EML, Moy HY, Chan ECY. Chen J, et al. Arch Toxicol. 2025 Jan 3. doi: 10.1007/s00204-024-03952-7. Online ahead of print. Arch Toxicol. 2025. PMID: 39751877
We identified 2-(4-hydroxy-1H-indol-3-yl)-acetaldehyde (4-HIA) as the Phase I intermediate metabolite for the first time. Psilocin was metabolized to 4-HIA by monoamine oxidase A (MAO-A), and further metabolized to the terminal metabolite 2-(4-hydroxy-1H-indol-3-yl) …
We identified 2-(4-hydroxy-1H-indol-3-yl)-acetaldehyde (4-HIA) as the Phase I intermediate metabolite for the first time. Psilocin was metab …
Evolutionary and Functional Analysis of Monoamine Oxidase F (MAO F): A Novel Member of the MAO Gene Family.
Merello Oyarzún G, Olivares-Costa M, Basile L, Pástor TP, Mendoza-Soto P, Padilla-Santiago L, Mardones GA, Binda C, Opazo JC. Merello Oyarzún G, et al. Genome Biol Evol. 2025 Jan 3:evae280. doi: 10.1093/gbe/evae280. Online ahead of print. Genome Biol Evol. 2025. PMID: 39749937
The monoamine oxidase (MAO) gene family encodes for enzymes that perform the oxidative deamination of monoamines, a process required to degrade norepinephrine, serotonin, dopamine, and other amines. While mammalian MAO enzymes, MAO A and MAO B, have be …
The monoamine oxidase (MAO) gene family encodes for enzymes that perform the oxidative deamination of monoamines, a process re …
A monoamine oxidase B inhibitor altered gene expression of catalytically active dual-specificity phosphatases in human oral gingival keratinocytes.
Ostadkarampour M, Putnins EE. Ostadkarampour M, et al. Eur Rev Med Pharmacol Sci. 2024 Dec;28(24):4681-4690. doi: 10.26355/eurrev_202412_37002. Eur Rev Med Pharmacol Sci. 2024. PMID: 39749374
OBJECTIVE: Monoamine oxidase (MAO) inhibitors reduce inflammation in a number of in vitro and in vivo models. This finding led to the development of a novel MAO-B selective inhibitor (RG0216) designed to reduce blood-brain barrier penetration. ...
OBJECTIVE: Monoamine oxidase (MAO) inhibitors reduce inflammation in a number of in vitro and in vivo models. This finding led …
Organotin(IV) derivatives of 4-chloro-2-methylphenoxyacetic acid: synthesis, spectral characterization, X-ray structures, anticancer, enzyme inhibition, antileishmanial, antimicrobial and antioxidant activities.
Rahim S, Sadiq A, Javed A, Muhammad N, Shaik MR, Assal ME, Kubicki M, Ayub K, Fatima N, Haider A, Habib S, Sarfaraz S, Ali S. Rahim S, et al. J Biomol Struct Dyn. 2025 Jan 3:1-16. doi: 10.1080/07391102.2024.2438362. Online ahead of print. J Biomol Struct Dyn. 2025. PMID: 39748662
Complex 4 was the most efficient inhibitor of MAO-B and COX-2 enzymes with IC(50) values of 106.99 and 12.98 g/mL, respectively, while 1 (IC(50) = 38.97 g/mL) has shown the highest 5-LOX inhibition potential. ...
Complex 4 was the most efficient inhibitor of MAO-B and COX-2 enzymes with IC(50) values of 106.99 and 12.98 g/mL, respectivel …
New class of thio/semicarbazide-based benzyloxy derivatives as selective class of monoamine oxidase-B inhibitors.
Chandran N, Lee J, Prabhakaran P, Kumar S, Sudevan ST, Parambi DGT, Alsahli TG, Pant M, Kim H, Mathew B. Chandran N, et al. Sci Rep. 2024 Dec 28;14(1):31292. doi: 10.1038/s41598-024-82771-3. Sci Rep. 2024. PMID: 39732801 Free PMC article.
Sixteen thio/semicarbazide-based benzyloxy derivatives (BT1-BT16) were synthesized and evaluated for their inhibitory activities against monoamine oxidases (MAOs). Most compounds showed better inhibitory activity against MAO-B than against MAO-A. ...BT1 and B …
Sixteen thio/semicarbazide-based benzyloxy derivatives (BT1-BT16) were synthesized and evaluated for their inhibitory activities against …
Effects of MAO-B inhibitors in life quality of Parkinson's disease patients: A systematic review and meta-analysis.
Liu X, Su J, Zhang J, Li Z, Huang K, Lin D, Tao E. Liu X, et al. Behav Brain Res. 2024 Dec 26;480:115410. doi: 10.1016/j.bbr.2024.115410. Online ahead of print. Behav Brain Res. 2024. PMID: 39732440
INTRODUCTION: Monoamine oxidase-B (MAO-B) inhibitors, as an add-on therapy to levodopa, are widely used in Parkinson's disease (PD). The effects of MAO-B inhibitors on quality of life remain unclear, and the aim of this systematic review …
INTRODUCTION: Monoamine oxidase-B (MAO-B) inhibitors, as an add-on therapy to levodopa, are widely used in Parki …
Ketamine impairs the performance of male mice in novel recognition object test and reduces the immunoreactivity of GAD67 in the hippocampus: Role of pioglitazone.
Rodrigues T, Bressan GN, Juliani PZ, da Silva MEB, Fachinetto R. Rodrigues T, et al. Pharmacol Biochem Behav. 2024 Dec 24;247:173950. doi: 10.1016/j.pbb.2024.173950. Online ahead of print. Pharmacol Biochem Behav. 2024. PMID: 39725040
We investigated the effects of pioglitazone, an agonist of PPAR-gamma, on the behavioral alterations induced by ketamine and, whether alterations in monoamine oxidase (MAO) activity, glutamic acid decarboxylase (GAD(67)), PPAR-gamma or tyrosine hydroxylase (TH) immu …
We investigated the effects of pioglitazone, an agonist of PPAR-gamma, on the behavioral alterations induced by ketamine and, whether altera …
Network Pharmacology and Metabolomics Reveal Anti-Ferroptotic Effects of Curcumin in Acute Kidney Injury.
Liu X, Zhou Y, Lu Z, Yang F, Wang Y, Zhang S, Zhang J, Zou H, Lin M. Liu X, et al. Drug Des Devel Ther. 2024 Dec 21;18:6223-6241. doi: 10.2147/DDDT.S486286. eCollection 2024. Drug Des Devel Ther. 2024. PMID: 39722679 Free PMC article.
Evidences suggest that ferroptosis is the primary cause of AKI, while inhibition of monoamine oxidase A(MAOA) and 5-hydroxytryptamine were recognized as the defender of ferroptosis. ...
Evidences suggest that ferroptosis is the primary cause of AKI, while inhibition of monoamine oxidase A(MAOA) and 5-hydroxytry …
Recent advances in potential enzymes and their therapeutic inhibitors for the treatment of Alzheimer's disease.
Vahid ZF, Eskandani M, Dadashi H, Vandghanooni S, Rashidi MR. Vahid ZF, et al. Heliyon. 2024 Nov 28;10(23):e40756. doi: 10.1016/j.heliyon.2024.e40756. eCollection 2024 Dec 15. Heliyon. 2024. PMID: 39717593 Free PMC article. Review.
In this review, the molecular mechanisms involved in the pathogenesis of AD were overviewed and various enzymes such as acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), beta-secretase, gamma-secretase, monoamine oxidase (MAO), and receptor of advanced gly …
In this review, the molecular mechanisms involved in the pathogenesis of AD were overviewed and various enzymes such as acetylcholinesterase …
27,394 results
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