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Hexamethylene amiloride engages a novel reactive oxygen species- and lysosome-dependent programmed necrotic mechanism to selectively target breast cancer cells.
Rowson-Hodel AR, Berg AL, Wald JH, Hatakeyama J, VanderVorst K, Curiel DA, Leon LJ, Sweeney C, Carraway KL 3rd. Rowson-Hodel AR, et al. Among authors: hatakeyama j. Cancer Lett. 2016 May 28;375(1):62-72. doi: 10.1016/j.canlet.2016.02.042. Epub 2016 Mar 2. Cancer Lett. 2016. PMID: 26944316 Free PMC article.
The Cationic Amphiphilic Drug Hexamethylene Amiloride Eradicates Bulk Breast Cancer Cells and Therapy-Resistant Subpopulations with Similar Efficiencies.
Berg AL, Rowson-Hodel A, Hu M, Keeling M, Wu H, VanderVorst K, Chen JJ, Hatakeyama J, Jilek J, Dreyer CA, Wheeler MR, Yu AM, Li Y, Carraway KL 3rd. Berg AL, et al. Among authors: hatakeyama j. Cancers (Basel). 2022 Feb 14;14(4):949. doi: 10.3390/cancers14040949. Cancers (Basel). 2022. PMID: 35205696 Free PMC article.
110 results