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Page 1
Structural interplay of KV7.1 and KCNE1 is essential for normal repolarization and is compromised in short QT syndrome 2 (KV7.1-A287T).
Rothenberg I, Piccini I, Wrobel E, Stallmeyer B, Müller J, Greber B, Strutz-Seebohm N, Schulze-Bahr E, Schmitt N, Seebohm G. Rothenberg I, et al. Among authors: schmitt n. HeartRhythm Case Rep. 2016 Sep 12;2(6):521-529. doi: 10.1016/j.hrcr.2016.08.015. eCollection 2016 Nov. HeartRhythm Case Rep. 2016. PMID: 28491751 Free PMC article. No abstract available.
A benzodiazepine activator locks Kv7.1 channels open by electro-mechanical uncoupling.
Schreiber JA, Möller M, Zaydman M, Zhao L, Beller Z, Becker S, Ritter N, Hou P, Shi J, Silva J, Wrobel E, Strutz-Seebohm N, Decher N, Schmitt N, Meuth SG, Düfer M, Wünsch B, Cui J, Seebohm G. Schreiber JA, et al. Among authors: schmitt n. Commun Biol. 2022 Apr 1;5(1):301. doi: 10.1038/s42003-022-03229-8. Commun Biol. 2022. PMID: 35365746 Free PMC article.
The novel C-terminal KCNQ1 mutation M520R alters protein trafficking.
Schmitt N, Calloe K, Nielsen NH, Buschmann M, Speckmann EJ, Schulze-Bahr E, Schwarz M. Schmitt N, et al. Biochem Biophys Res Commun. 2007 Jun 22;358(1):304-10. doi: 10.1016/j.bbrc.2007.04.127. Epub 2007 Apr 27. Biochem Biophys Res Commun. 2007. PMID: 17482572
Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis.
Liang B, Soka M, Christensen AH, Olesen MS, Larsen AP, Knop FK, Wang F, Nielsen JB, Andersen MN, Humphreys D, Mann SA, Huttner IG, Vandenberg JI, Svendsen JH, Haunsø S, Preiss T, Seebohm G, Olesen SP, Schmitt N, Fatkin D. Liang B, et al. Among authors: schmitt n. J Mol Cell Cardiol. 2014 Feb;67:69-76. doi: 10.1016/j.yjmcc.2013.12.014. Epub 2013 Dec 27. J Mol Cell Cardiol. 2014. PMID: 24374141
412 results