Georgoff PE - Search Results

1

Safety and Tolerability of Intravenous Valproic Acid in Healthy Subjects: A Phase I Dose-Escalation Trial.

Georgoff PE, Nikolian VC, Bonham T, Pai MP, Tafatia C, Halaweish I, To K, Watcharotone K, Parameswaran A, Luo R, Sun D, Alam HB. Georgoff PE, et al. Clin Pharmacokinet. 2018 Feb;57(2):209-219. doi: 10.1007/s40262-017-0553-1. Clin Pharmacokinet. 2018. PMID: 28497259 Free PMC article. Clinical Trial.

2

Alterations in the human proteome following administration of valproic acid.

Georgoff PE, Halaweish I, Nikolian VC, Higgins GA, Bonham T, Tafatia C, Remmer H, Menon R, Liu B, Li Y, Alam HB. Georgoff PE, et al. J Trauma Acute Care Surg. 2016 Dec;81(6):1020-1027. doi: 10.1097/TA.0000000000001249. J Trauma Acute Care Surg. 2016. PMID: 27602906 Clinical Trial.

3

Physiologically based pharmacokinetic modeling of disposition and drug-drug interactions for valproic acid and divalproex.

Conner TM, Nikolian VC, Georgoff PE, Pai MP, Alam HB, Sun D, Reed RC, Zhang T. Conner TM, et al. Among authors: georgoff pe. Eur J Pharm Sci. 2018 Jan 1;111:465-481. doi: 10.1016/j.ejps.2017.10.009. Epub 2017 Oct 10. Eur J Pharm Sci. 2018. PMID: 29030176 Free PMC article.

4

Rapid valproic acid-induced modulation of the traumatic proteome in a porcine model of traumatic brain injury and hemorrhagic shock.

Weykamp M, Nikolian VC, Dennahy IS, Higgins GA, Georgoff PE, Remmer H, Ghandour MH, Alam HB. Weykamp M, et al. Among authors: georgoff pe. J Surg Res. 2018 Aug;228:84-92. doi: 10.1016/j.jss.2018.02.046. Epub 2018 Apr 25. J Surg Res. 2018. PMID: 29907235

5

Resuscitation with Lyophilized Plasma Is Safe and Improves Neurological Recovery in a Long-Term Survival Model of Swine Subjected to Traumatic Brain Injury, Hemorrhagic Shock, and Polytrauma.

Georgoff PE, Nikolian VC, Halaweish I, Chtraklin K, Bruhn PJ, Eidy H, Rasmussen M, Li Y, Srinivasan A, Alam HB. Georgoff PE, et al. J Neurotrauma. 2017 Jul 1;34(13):2167-2175. doi: 10.1089/neu.2016.4859. Epub 2017 Apr 25. J Neurotrauma. 2017. PMID: 28228060

6

Valproic acid modulates platelet and coagulation function ex vivo.

Bambakidis T, Dekker SE, Halaweish I, Liu B, Nikolian VC, Georgoff PE, Piascik P, Li Y, Sillesen M, Alam HB. Bambakidis T, et al. Among authors: georgoff pe. Blood Coagul Fibrinolysis. 2017 Sep;28(6):479-484. doi: 10.1097/MBC.0000000000000626. Blood Coagul Fibrinolysis. 2017. PMID: 28230635

7

Valproic acid decreases brain lesion size and improves neurologic recovery in swine subjected to traumatic brain injury, hemorrhagic shock, and polytrauma.

Nikolian VC, Georgoff PE, Pai MP, Dennahy IS, Chtraklin K, Eidy H, Ghandour MH, Han Y, Srinivasan A, Li Y, Alam HB. Nikolian VC, et al. Among authors: georgoff pe. J Trauma Acute Care Surg. 2017 Dec;83(6):1066-1073. doi: 10.1097/TA.0000000000001612. J Trauma Acute Care Surg. 2017. PMID: 28697014

8

Improvement of Blood-Brain Barrier Integrity in Traumatic Brain Injury and Hemorrhagic Shock Following Treatment With Valproic Acid and Fresh Frozen Plasma.

Nikolian VC, Dekker SE, Bambakidis T, Higgins GA, Dennahy IS, Georgoff PE, Williams AM, Andjelkovic AV, Alam HB. Nikolian VC, et al. Among authors: georgoff pe. Crit Care Med. 2018 Jan;46(1):e59-e66. doi: 10.1097/CCM.0000000000002800. Crit Care Med. 2018. PMID: 29095204

9

Valproic acid induces prosurvival transcriptomic changes in swine subjected to traumatic injury and hemorrhagic shock.

Georgoff PE, Nikolian VC, Higgins G, Chtraklin K, Eidy H, Ghandour MH, Williams A, Athey B, Alam HB. Georgoff PE, et al. J Trauma Acute Care Surg. 2018 Apr;84(4):642-649. doi: 10.1097/TA.0000000000001763. J Trauma Acute Care Surg. 2018. PMID: 29251706

10

Transcriptomic changes following valproic acid treatment promote neurogenesis and minimize secondary brain injury.

Nikolian VC, Dennahy IS, Higgins GA, Williams AM, Weykamp M, Georgoff PE, Eidy H, Ghandour MH, Chang P, Alam HB. Nikolian VC, et al. Among authors: georgoff pe. J Trauma Acute Care Surg. 2018 Mar;84(3):459-465. doi: 10.1097/TA.0000000000001765. J Trauma Acute Care Surg. 2018. PMID: 29251707 Free PMC article.

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