Mark BL - Search Results

1

Selective trihydroxylated azepane inhibitors of NagZ, a glycosidase involved in Pseudomonas aeruginosa resistance to β-lactam antibiotics.

Bouquet J, King DT, Vadlamani G, Benzie GR, Iorga B, Ide D, Adachi I, Kato A, Vocadlo DJ, Mark BL, Blériot Y, Désiré J. Bouquet J, et al. Among authors: mark bl. Org Biomol Chem. 2017 May 31;15(21):4609-4619. doi: 10.1039/c7ob00838d. Org Biomol Chem. 2017. PMID: 28513749 Free article.

2

Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams.

Mondon M, Hur S, Vadlamani G, Rodrigues P, Tsybina P, Oliver A, Mark BL, Vocadlo DJ, Blériot Y. Mondon M, et al. Among authors: mark bl. Chem Commun (Camb). 2013 Dec 4;49(93):10983-5. doi: 10.1039/c3cc46646a. Chem Commun (Camb). 2013. PMID: 24136176

3

Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance.

Vadlamani G, Stubbs KA, Désiré J, Blériot Y, Vocadlo DJ, Mark BL. Vadlamani G, et al. Among authors: mark bl. Protein Sci. 2017 Jun;26(6):1161-1170. doi: 10.1002/pro.3166. Epub 2017 Apr 7. Protein Sci. 2017. PMID: 28370529 Free PMC article.

4

Inactivation of the glycoside hydrolase NagZ attenuates antipseudomonal beta-lactam resistance in Pseudomonas aeruginosa.

Asgarali A, Stubbs KA, Oliver A, Vocadlo DJ, Mark BL. Asgarali A, et al. Among authors: mark bl. Antimicrob Agents Chemother. 2009 Jun;53(6):2274-82. doi: 10.1128/AAC.01617-08. Epub 2009 Mar 9. Antimicrob Agents Chemother. 2009. PMID: 19273679 Free PMC article.

5

Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance.

Stubbs KA, Balcewich M, Mark BL, Vocadlo DJ. Stubbs KA, et al. Among authors: mark bl. J Biol Chem. 2007 Jul 20;282(29):21382-91. doi: 10.1074/jbc.M700084200. Epub 2007 Apr 16. J Biol Chem. 2007. PMID: 17439950 Free article.

6

Providing β-lactams a helping hand: targeting the AmpC β-lactamase induction pathway.

Mark BL, Vocadlo DJ, Oliver A. Mark BL, et al. Future Microbiol. 2011 Dec;6(12):1415-27. doi: 10.2217/fmb.11.128. Future Microbiol. 2011. PMID: 22122439 Review.

7

The development of selective inhibitors of NagZ: increased susceptibility of Gram-negative bacteria to β-lactams.

Stubbs KA, Bacik JP, Perley-Robertson GE, Whitworth GE, Gloster TM, Vocadlo DJ, Mark BL. Stubbs KA, et al. Among authors: mark bl. Chembiochem. 2013 Oct 11;14(15):1973-81. doi: 10.1002/cbic.201300395. Epub 2013 Sep 5. Chembiochem. 2013. PMID: 24009110 Free PMC article.

8

A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa.

Ho LA, Winogrodzki JL, Debowski AW, Madden Z, Vocadlo DJ, Mark BL, Stubbs KA. Ho LA, et al. Among authors: mark bl. Chem Commun (Camb). 2018 Sep 25;54(75):10630-10633. doi: 10.1039/c8cc05281f. Epub 2018 Sep 4. Chem Commun (Camb). 2018. PMID: 30178799

9

Synthesis and use of mechanism-based protein-profiling probes for retaining beta-D-glucosaminidases facilitate identification of Pseudomonas aeruginosa NagZ.

Stubbs KA, Scaffidi A, Debowski AW, Mark BL, Stick RV, Vocadlo DJ. Stubbs KA, et al. Among authors: mark bl. J Am Chem Soc. 2008 Jan 9;130(1):327-35. doi: 10.1021/ja0763605. Epub 2007 Dec 8. J Am Chem Soc. 2008. PMID: 18067297

10

Insight into a strategy for attenuating AmpC-mediated beta-lactam resistance: structural basis for selective inhibition of the glycoside hydrolase NagZ.

Balcewich MD, Stubbs KA, He Y, James TW, Davies GJ, Vocadlo DJ, Mark BL. Balcewich MD, et al. Among authors: mark bl. Protein Sci. 2009 Jul;18(7):1541-51. doi: 10.1002/pro.137. Protein Sci. 2009. PMID: 19499593 Free PMC article.

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