Copple IM - Search Results

1

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.

O'Neill PM, Amewu RK, Charman SA, Sabbani S, Gnädig NF, Straimer J, Fidock DA, Shore ER, Roberts NL, Wong MH, Hong WD, Pidathala C, Riley C, Murphy B, Aljayyoussi G, Gamo FJ, Sanz L, Rodrigues J, Cortes CG, Herreros E, Angulo-Barturén I, Jiménez-Díaz MB, Bazaga SF, Martínez-Martínez MS, Campo B, Sharma R, Ryan E, Shackleford DM, Campbell S, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Palmer MJ, Copple IM, Mercer AE, Ruecker A, Delves MJ, Sinden RE, Siegl P, Davies J, Rochford R, Kocken CHM, Zeeman AM, Nixon GL, Biagini GA, Ward SA. O'Neill PM, et al. Among authors: copple im. Nat Commun. 2017 May 24;8:15159. doi: 10.1038/ncomms15159. Nat Commun. 2017. PMID: 28537265 Free PMC article.

2

The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials.

Mercer AE, Copple IM, Maggs JL, O'Neill PM, Park BK. Mercer AE, et al. Among authors: copple im. J Biol Chem. 2011 Jan 14;286(2):987-96. doi: 10.1074/jbc.M110.144188. Epub 2010 Nov 8. J Biol Chem. 2011. PMID: 21059641 Free PMC article.

3

Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials.

Copple IM, Mercer AE, Firman J, Donegan G, Herpers B, Wong MH, Chadwick J, Bringela AD, Cristiano ML, van de Water B, Ward SA, O'Neill PM, Park BK. Copple IM, et al. Mol Med. 2012 Sep 25;18(1):1045-55. doi: 10.2119/molmed.2012.00154. Mol Med. 2012. PMID: 22669474 Free PMC article.

4

Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications.

Walsh J, Jenkins RE, Wong M, Olayanju A, Powell H, Copple I, O'Neill PM, Goldring CE, Kitteringham NR, Park BK. Walsh J, et al. J Proteomics. 2014 Aug 28;108(100):171-87. doi: 10.1016/j.jprot.2014.05.007. Epub 2014 May 21. J Proteomics. 2014. PMID: 24859727 Free PMC article.

5

Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney.

Shelton LM, Lister A, Walsh J, Jenkins RE, Wong MH, Rowe C, Ricci E, Ressel L, Fang Y, Demougin P, Vukojevic V, O'Neill PM, Goldring CE, Kitteringham NR, Park BK, Odermatt A, Copple IM. Shelton LM, et al. Among authors: copple im. Kidney Int. 2015 Dec;88(6):1261-1273. doi: 10.1038/ki.2015.286. Epub 2015 Sep 30. Kidney Int. 2015. PMID: 26422507 Free PMC article.

6

Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites.

Wong MH, Bryan HK, Copple IM, Jenkins RE, Chiu PH, Bibby J, Berry NG, Kitteringham NR, Goldring CE, O'Neill PM, Park BK. Wong MH, et al. Among authors: copple im. J Med Chem. 2016 Mar 24;59(6):2396-409. doi: 10.1021/acs.jmedchem.5b01292. Epub 2016 Mar 8. J Med Chem. 2016. PMID: 26908173 Free article.

7

Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity.

Forootan SS, Mutter FE, Kipar A, Iwawaki T, Francis B, Goldring CE, Park BK, Copple IM. Forootan SS, et al. Among authors: copple im. Sci Rep. 2017 Nov 22;7(1):16084. doi: 10.1038/s41598-017-16491-2. Sci Rep. 2017. PMID: 29167567 Free PMC article.

8

Plasticity in cell defence: access to and reactivity of critical protein residues and DNA response elements.

Goldring C, Kitteringham N, Jenkins R, Copple I, Jeannin JF, Park BK. Goldring C, et al. J Exp Biol. 2006 Jun;209(Pt 12):2337-43. doi: 10.1242/jeb.02209. J Exp Biol. 2006. PMID: 16731810 Review.

9

Extract of Ginkgo biloba induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway.

Liu XP, Goldring CE, Copple IM, Wang HY, Wei W, Kitteringham NR, Park BK. Liu XP, et al. Among authors: copple im. Life Sci. 2007 Apr 3;80(17):1586-91. doi: 10.1016/j.lfs.2007.01.034. Epub 2007 Jan 27. Life Sci. 2007. PMID: 17316704

10

The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity.

Copple IM, Goldring CE, Kitteringham NR, Park BK. Copple IM, et al. Toxicology. 2008 Apr 3;246(1):24-33. doi: 10.1016/j.tox.2007.10.029. Epub 2007 Nov 12. Toxicology. 2008. PMID: 18083283 Review.

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