Roose JP - Search Results

1

Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.

Myers DR, Lau T, Markegard E, Lim HW, Kasler H, Zhu M, Barczak A, Huizar JP, Zikherman J, Erle DJ, Zhang W, Verdin E, Roose JP. Myers DR, et al. Among authors: roose jp. Cell Rep. 2017 May 23;19(8):1558-1571. doi: 10.1016/j.celrep.2017.04.076. Cell Rep. 2017. PMID: 28538176 Free PMC article.

2

Origin of the sharp boundary that discriminates positive and negative selection of thymocytes.

Prasad A, Zikherman J, Das J, Roose JP, Weiss A, Chakraborty AK. Prasad A, et al. Among authors: roose jp. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):528-33. doi: 10.1073/pnas.0805981105. Epub 2008 Dec 19. Proc Natl Acad Sci U S A. 2009. PMID: 19098101 Free PMC article.

3

Digital signaling and hysteresis characterize ras activation in lymphoid cells.

Das J, Ho M, Zikherman J, Govern C, Yang M, Weiss A, Chakraborty AK, Roose JP. Das J, et al. Among authors: roose jp. Cell. 2009 Jan 23;136(2):337-51. doi: 10.1016/j.cell.2008.11.051. Cell. 2009. PMID: 19167334 Free PMC article.

4

Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes.

Chakraborty AK, Das J, Zikherman J, Yang M, Govern CC, Ho M, Weiss A, Roose J. Chakraborty AK, et al. Sci Signal. 2009 Apr 14;2(66):pt2. doi: 10.1126/scisignal.266pt2. Sci Signal. 2009. PMID: 19366993 Free PMC article.

5

Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression.

Markegard E, Trager E, Yang CW, Zhang W, Weiss A, Roose JP. Markegard E, et al. Among authors: roose jp. PLoS One. 2011;6(9):e25540. doi: 10.1371/journal.pone.0025540. Epub 2011 Sep 26. PLoS One. 2011. PMID: 21966541 Free PMC article.

6

A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.

Kortum RL, Rouquette-Jazdanian AK, Miyaji M, Merrill RK, Markegard E, Pinski JM, Wesselink A, Nath NN, Alexander CP, Li W, Kedei N, Roose JP, Blumberg PM, Samelson LE, Sommers CL. Kortum RL, et al. Among authors: roose jp. J Immunol. 2013 Jan 1;190(1):147-58. doi: 10.4049/jimmunol.1201458. Epub 2012 Dec 3. J Immunol. 2013. PMID: 23209318 Free PMC article.

7

Protein kinase Cδ promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance.

Limnander A, Zikherman J, Lau T, Leitges M, Weiss A, Roose JP. Limnander A, et al. Among authors: roose jp. Mol Cell Biol. 2014 Apr;34(8):1474-85. doi: 10.1128/MCB.01699-13. Epub 2014 Feb 10. Mol Cell Biol. 2014. PMID: 24515435 Free PMC article.

8

Tonic Signals: Why Do Lymphocytes Bother?

Myers DR, Zikherman J, Roose JP. Myers DR, et al. Among authors: roose jp. Trends Immunol. 2017 Nov;38(11):844-857. doi: 10.1016/j.it.2017.06.010. Epub 2017 Jul 25. Trends Immunol. 2017. PMID: 28754596 Free PMC article. Review.

9

High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions.

Mues M, Karra L, Romero-Moya D, Wandler A, Hangauer MJ, Ksionda O, Thus Y, Lindenbergh M, Shannon K, McManus MT, Roose JP. Mues M, et al. Among authors: roose jp. Cell Rep. 2019 Apr 9;27(2):631-647.e5. doi: 10.1016/j.celrep.2019.03.045. Cell Rep. 2019. PMID: 30970263 Free PMC article.

10

Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells.

Myers DR, Norlin E, Vercoulen Y, Roose JP. Myers DR, et al. Among authors: roose jp. Cell Rep. 2019 May 7;27(6):1858-1874.e6. doi: 10.1016/j.celrep.2019.04.037. Cell Rep. 2019. PMID: 31067469 Free PMC article.

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