Hu F - Search Results

1

Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations.

Zhou X, Sun L, Bracko O, Choi JW, Jia Y, Nana AL, Brady OA, Hernandez JCC, Nishimura N, Seeley WW, Hu F. Zhou X, et al. Among authors: hu f. Nat Commun. 2017 May 25;8:15277. doi: 10.1038/ncomms15277. Nat Commun. 2017. PMID: 28541286 Free PMC article.

2

Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1.

Brady OA, Meng P, Zheng Y, Mao Y, Hu F. Brady OA, et al. Among authors: hu f. J Neurochem. 2011 Jan;116(2):248-59. doi: 10.1111/j.1471-4159.2010.07098.x. Epub 2010 Dec 2. J Neurochem. 2011. PMID: 21062285 Free article.

3

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

Hu F, Padukkavidana T, Vægter CB, Brady OA, Zheng Y, Mackenzie IR, Feldman HH, Nykjaer A, Strittmatter SM. Hu F, et al. Neuron. 2010 Nov 18;68(4):654-67. doi: 10.1016/j.neuron.2010.09.034. Neuron. 2010. PMID: 21092856 Free PMC article.

4

C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking.

Zheng Y, Brady OA, Meng PS, Mao Y, Hu F. Zheng Y, et al. Among authors: hu f. PLoS One. 2011;6(6):e21023. doi: 10.1371/journal.pone.0021023. Epub 2011 Jun 15. PLoS One. 2011. PMID: 21698296 Free PMC article.

5

The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function.

Brady OA, Zheng Y, Murphy K, Huang M, Hu F. Brady OA, et al. Among authors: hu f. Hum Mol Genet. 2013 Feb 15;22(4):685-95. doi: 10.1093/hmg/dds475. Epub 2012 Nov 6. Hum Mol Genet. 2013. PMID: 23136129 Free PMC article.

6

Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain.

Busch JI, Martinez-Lage M, Ashbridge E, Grossman M, Van Deerlin VM, Hu F, Lee VM, Trojanowski JQ, Chen-Plotkin AS. Busch JI, et al. Among authors: hu f. Acta Neuropathol Commun. 2013 Jul 11;1:36. doi: 10.1186/2051-5960-1-36. Acta Neuropathol Commun. 2013. PMID: 24252750 Free PMC article.

7

Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a).

Brady OA, Zhou X, Hu F. Brady OA, et al. Among authors: hu f. J Biol Chem. 2014 Jul 11;289(28):19670-80. doi: 10.1074/jbc.M113.515700. Epub 2014 May 28. J Biol Chem. 2014. PMID: 24872421 Free PMC article.

8

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.

Zhou X, Sun L, Bastos de Oliveira F, Qi X, Brown WJ, Smolka MB, Sun Y, Hu F. Zhou X, et al. Among authors: hu f. J Cell Biol. 2015 Sep 14;210(6):991-1002. doi: 10.1083/jcb.201502029. J Cell Biol. 2015. PMID: 26370502 Free PMC article.

9

The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway.

Sullivan PM, Zhou X, Robins AM, Paushter DH, Kim D, Smolka MB, Hu F. Sullivan PM, et al. Among authors: hu f. Acta Neuropathol Commun. 2016 May 18;4(1):51. doi: 10.1186/s40478-016-0324-5. Acta Neuropathol Commun. 2016. PMID: 27193190 Free PMC article.

10

Elevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiency.

Zhou X, Sun L, Brady OA, Murphy KA, Hu F. Zhou X, et al. Among authors: hu f. Acta Neuropathol Commun. 2017 Jan 26;5(1):9. doi: 10.1186/s40478-017-0412-1. Acta Neuropathol Commun. 2017. PMID: 28126008 Free PMC article.

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