Araki T - Search Results

1

Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome.

Yin JC, Platt MJ, Tian X, Wu X, Backx PH, Simpson JA, Araki T, Neel BG. Yin JC, et al. Among authors: araki t. Nat Commun. 2017 May 26;8:15518. doi: 10.1038/ncomms15518. Nat Commun. 2017. PMID: 28548091 Free PMC article.

2

MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation.

Wu X, Simpson J, Hong JH, Kim KH, Thavarajah NK, Backx PH, Neel BG, Araki T. Wu X, et al. Among authors: araki t. J Clin Invest. 2011 Mar;121(3):1009-25. doi: 10.1172/JCI44929. Epub 2011 Feb 21. J Clin Invest. 2011. PMID: 21339642 Free PMC article.

3

Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants.

Wu X, Yin J, Simpson J, Kim KH, Gu S, Hong JH, Bayliss P, Backx PH, Neel BG, Araki T. Wu X, et al. Among authors: araki t. Mol Cell Biol. 2012 Oct;32(19):3872-90. doi: 10.1128/MCB.00751-12. Epub 2012 Jul 23. Mol Cell Biol. 2012. PMID: 22826437 Free PMC article.

4

Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation.

Araki T, Chan G, Newbigging S, Morikawa L, Bronson RT, Neel BG. Araki T, et al. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4736-41. doi: 10.1073/pnas.0810053106. Epub 2009 Feb 27. Proc Natl Acad Sci U S A. 2009. PMID: 19251646 Free PMC article.

5

Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome.

Lee YS, Ehninger D, Zhou M, Oh JY, Kang M, Kwak C, Ryu HH, Butz D, Araki T, Cai Y, Balaji J, Sano Y, Nam CI, Kim HK, Kaang BK, Burger C, Neel BG, Silva AJ. Lee YS, et al. Among authors: araki t. Nat Neurosci. 2014 Dec;17(12):1736-43. doi: 10.1038/nn.3863. Epub 2014 Nov 10. Nat Neurosci. 2014. PMID: 25383899 Free PMC article.

6

Noonan syndrome-causing SHP2 mutants impair ERK-dependent chondrocyte differentiation during endochondral bone growth.

Tajan M, Pernin-Grandjean J, Beton N, Gennero I, Capilla F, Neel BG, Araki T, Valet P, Tauber M, Salles JP, Yart A, Edouard T. Tajan M, et al. Among authors: araki t. Hum Mol Genet. 2018 Jul 1;27(13):2276-2289. doi: 10.1093/hmg/ddy133. Hum Mol Genet. 2018. PMID: 29659837 Free PMC article.

7

The Noonan Syndrome-linked Raf1L613V mutation drives increased glial number in the mouse cortex and enhanced learning.

Holter MC, Hewitt LT, Koebele SV, Judd JM, Xing L, Bimonte-Nelson HA, Conrad CD, Araki T, Neel BG, Snider WD, Newbern JM. Holter MC, et al. Among authors: araki t. PLoS Genet. 2019 Apr 24;15(4):e1008108. doi: 10.1371/journal.pgen.1008108. eCollection 2019 Apr. PLoS Genet. 2019. PMID: 31017896 Free PMC article.

8

Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation.

Araki T, Mohi MG, Ismat FA, Bronson RT, Williams IR, Kutok JL, Yang W, Pao LI, Gilliland DG, Epstein JA, Neel BG. Araki T, et al. Nat Med. 2004 Aug;10(8):849-57. doi: 10.1038/nm1084. Epub 2004 Jul 25. Nat Med. 2004. PMID: 15273746

9

Control of CNS cell-fate decisions by SHP-2 and its dysregulation in Noonan syndrome.

Gauthier AS, Furstoss O, Araki T, Chan R, Neel BG, Kaplan DR, Miller FD. Gauthier AS, et al. Among authors: araki t. Neuron. 2007 Apr 19;54(2):245-62. doi: 10.1016/j.neuron.2007.03.027. Neuron. 2007. PMID: 17442246 Free PMC article.

10

Sticking It to Cancer with Molecular Glue for SHP2.

Ran H, Tsutsumi R, Araki T, Neel BG. Ran H, et al. Among authors: araki t. Cancer Cell. 2016 Aug 8;30(2):194-196. doi: 10.1016/j.ccell.2016.07.010. Cancer Cell. 2016. PMID: 27505669 Free PMC article.

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