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Changes in the extracellular envelope glycoprotein of variants that evolve during the course of simian immunodeficiency virus SIVMne infection affect neutralizing antibody recognition, syncytium formation, and macrophage tropism but not replication, cytopathicity, or CCR-5 coreceptor recognition.
Rudensey LM, Kimata JT, Long EM, Chackerian B, Overbaugh J. Rudensey LM, et al. Among authors: overbaugh j. J Virol. 1998 Jan;72(1):209-17. doi: 10.1128/JVI.72.1.209-217.1998. J Virol. 1998. PMID: 9420217 Free PMC article.
Heavily glycosylated, highly fit SIVMne variants continue to diversify and undergo selection after transmission to a new host and they elicit early antibody dependent cellular responses but delayed neutralizing antibody responses.
Eastman D, Piantadosi A, Wu X, Forthal DN, Landucci G, Kimata JT, Overbaugh J. Eastman D, et al. Among authors: overbaugh j. Virol J. 2008 Aug 4;5:90. doi: 10.1186/1743-422X-5-90. Virol J. 2008. PMID: 18680596 Free PMC article.
362 results