Laurini E - Search Results

1

Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells.

Genini D, Brambilla L, Laurini E, Merulla J, Civenni G, Pandit S, D'Antuono R, Perez L, Levy DE, Pricl S, Carbone GM, Catapano CV. Genini D, et al. Among authors: laurini e. Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E4924-E4933. doi: 10.1073/pnas.1615730114. Epub 2017 Jun 5. Proc Natl Acad Sci U S A. 2017. PMID: 28584133 Free PMC article.

2

A 3D-pharmacophore model for sigma2 receptors based on a series of substituted benzo[d]oxazol-2(3H)-one derivatives.

Laurini E, Zampieri D, Mamolo MG, Vio L, Zanette C, Florio C, Posocco P, Fermeglia M, Pricl S. Laurini E, et al. Bioorg Med Chem Lett. 2010 May 1;20(9):2954-7. doi: 10.1016/j.bmcl.2010.03.009. Epub 2010 Mar 4. Bioorg Med Chem Lett. 2010. PMID: 20347592

3

Efficient delivery of sticky siRNA and potent gene silencing in a prostate cancer model using a generation 5 triethanolamine-core PAMAM dendrimer.

Liu X, Liu C, Laurini E, Posocco P, Pricl S, Qu F, Rocchi P, Peng L. Liu X, et al. Among authors: laurini e. Mol Pharm. 2012 Mar 5;9(3):470-81. doi: 10.1021/mp2006104. Epub 2012 Jan 20. Mol Pharm. 2012. PMID: 22208617

4

Another brick in the wall. Validation of the σ1 receptor 3D model by computer-assisted design, synthesis, and activity of new σ1 ligands.

Laurini E, Marson D, Dal Col V, Fermeglia M, Mamolo MG, Zampieri D, Vio L, Pricl S. Laurini E, et al. Mol Pharm. 2012 Nov 5;9(11):3107-26. doi: 10.1021/mp300233y. Epub 2012 Oct 12. Mol Pharm. 2012. PMID: 23020867

5

Analysis of the molecular interactions of the potent analgesic S1RA with the σ1 receptor.

Laurini E, Da Col V, Wünsch B, Pricl S. Laurini E, et al. Bioorg Med Chem Lett. 2013 May 15;23(10):2868-71. doi: 10.1016/j.bmcl.2013.03.087. Epub 2013 Mar 30. Bioorg Med Chem Lett. 2013. PMID: 23582276

6

Through the open door: Preferential binding of dasatinib to the active form of BCR-ABL unveiled by in silico experiments.

Laurini E, Posocco P, Fermeglia M, Gibbons DL, Quintás-Cardama A, Pricl S. Laurini E, et al. Mol Oncol. 2013 Oct;7(5):968-75. doi: 10.1016/j.molonc.2013.06.001. Epub 2013 Jun 15. Mol Oncol. 2013. PMID: 23816609 Free PMC article.

7

Impact of siRNA overhangs for dendrimer-mediated siRNA delivery and gene silencing.

Posocco P, Liu X, Laurini E, Marson D, Chen C, Liu C, Fermeglia M, Rocchi P, Pricl S, Peng L. Posocco P, et al. Among authors: laurini e. Mol Pharm. 2013 Aug 5;10(8):3262-73. doi: 10.1021/mp400329g. Epub 2013 Jul 25. Mol Pharm. 2013. PMID: 23841848

8

Structural requirements of 2-oxoglutaric acid analogues to mimic its signaling function.

Liu X, Wang Y, Laurini E, Posocco P, Chen H, Ziarelli F, Janicki A, Qu F, Fermeglia M, Pricl S, Zhang CC, Peng L. Liu X, et al. Among authors: laurini e. Org Lett. 2013 Sep 20;15(18):4662-5. doi: 10.1021/ol401914z. Epub 2013 Aug 29. Org Lett. 2013. PMID: 23988123

9

Synthesis and receptor binding studies of some new arylcarboxamide derivatives as sigma-1 ligands.

Zampieri D, Laurini E, Vio L, Golob S, Fermeglia M, Pricl S, Mamolo MG. Zampieri D, et al. Among authors: laurini e. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1021-5. doi: 10.1016/j.bmcl.2014.01.032. Epub 2014 Jan 20. Bioorg Med Chem Lett. 2014. PMID: 24486131

10

Molecular dynamics reveal BCR-ABL1 polymutants as a unique mechanism of resistance to PAN-BCR-ABL1 kinase inhibitor therapy.

Gibbons DL, Pricl S, Posocco P, Laurini E, Fermeglia M, Sun H, Talpaz M, Donato N, Quintás-Cardama A. Gibbons DL, et al. Among authors: laurini e. Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3550-5. doi: 10.1073/pnas.1321173111. Epub 2014 Feb 18. Proc Natl Acad Sci U S A. 2014. PMID: 24550512 Free PMC article.

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