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Dimethyl fumarate improves white matter function following severe hypoperfusion: Involvement of microglia/macrophages and inflammatory mediators.
Fowler JH, McQueen J, Holland PR, Manso Y, Marangoni M, Scott F, Chisholm E, Scannevin RH, Hardingham GE, Horsburgh K. Fowler JH, et al. Among authors: scannevin rh. J Cereb Blood Flow Metab. 2018 Aug;38(8):1354-1370. doi: 10.1177/0271678X17713105. Epub 2017 Jun 13. J Cereb Blood Flow Metab. 2018. PMID: 28606007 Free PMC article.
Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2.
Bell KF, Al-Mubarak B, Martel MA, McKay S, Wheelan N, Hasel P, Márkus NM, Baxter P, Deighton RF, Serio A, Bilican B, Chowdhry S, Meakin PJ, Ashford ML, Wyllie DJ, Scannevin RH, Chandran S, Hayes JD, Hardingham GE. Bell KF, et al. Among authors: scannevin rh. Nat Commun. 2015 May 13;6:7066. doi: 10.1038/ncomms8066. Nat Commun. 2015. PMID: 25967870 Free PMC article.
Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2.
Schulze-Topphoff U, Varrin-Doyer M, Pekarek K, Spencer CM, Shetty A, Sagan SA, Cree BA, Sobel RA, Wipke BT, Steinman L, Scannevin RH, Zamvil SS. Schulze-Topphoff U, et al. Among authors: scannevin rh. Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4777-82. doi: 10.1073/pnas.1603907113. Epub 2016 Apr 13. Proc Natl Acad Sci U S A. 2016. PMID: 27078105 Free PMC article.
Different Fumaric Acid Esters Elicit Distinct Pharmacologic Responses.
Wipke BT, Hoepner R, Strassburger-Krogias K, Thomas AM, Gianni D, Szak S, Brennan MS, Pistor M, Gold R, Chan A, Scannevin RH. Wipke BT, et al. Among authors: scannevin rh. Neurol Neuroimmunol Neuroinflamm. 2021 Jan 19;8(2):e950. doi: 10.1212/NXI.0000000000000950. Print 2021 Mar. Neurol Neuroimmunol Neuroinflamm. 2021. PMID: 33468560 Free PMC article.
58 results