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Cellular senescence drives age-dependent hepatic steatosis.
Ogrodnik M, Miwa S, Tchkonia T, Tiniakos D, Wilson CL, Lahat A, Day CP, Burt A, Palmer A, Anstee QM, Grellscheid SN, Hoeijmakers JHJ, Barnhoorn S, Mann DA, Bird TG, Vermeij WP, Kirkland JL, Passos JF, von Zglinicki T, Jurk D. Ogrodnik M, et al. Among authors: tchkonia t. Nat Commun. 2017 Jun 13;8:15691. doi: 10.1038/ncomms15691. Nat Commun. 2017. PMID: 28608850 Free PMC article.
Deleted in Breast Cancer 1 regulates cellular senescence during obesity.
Escande C, Nin V, Pirtskhalava T, Chini CC, Thereza Barbosa M, Mathison A, Urrutia R, Tchkonia T, Kirkland JL, Chini EN. Escande C, et al. Among authors: tchkonia t. Aging Cell. 2014 Oct;13(5):951-3. doi: 10.1111/acel.12235. Epub 2014 Jul 3. Aging Cell. 2014. PMID: 24992635 Free PMC article.
TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess.
Idrissova L, Malhi H, Werneburg NW, LeBrasseur NK, Bronk SF, Fingas C, Tchkonia T, Pirtskhalava T, White TA, Stout MB, Hirsova P, Krishnan A, Liedtke C, Trautwein C, Finnberg N, El-Deiry WS, Kirkland JL, Gores GJ. Idrissova L, et al. Among authors: tchkonia t. J Hepatol. 2015 May;62(5):1156-63. doi: 10.1016/j.jhep.2014.11.033. Epub 2014 Nov 28. J Hepatol. 2015. PMID: 25445398 Free PMC article.
Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue.
Sagar G, Sah RP, Javeed N, Dutta SK, Smyrk TC, Lau JS, Giorgadze N, Tchkonia T, Kirkland JL, Chari ST, Mukhopadhyay D. Sagar G, et al. Among authors: tchkonia t. Gut. 2016 Jul;65(7):1165-74. doi: 10.1136/gutjnl-2014-308350. Epub 2015 Apr 28. Gut. 2016. PMID: 26061593 Free PMC article.
Targeting senescent cells enhances adipogenesis and metabolic function in old age.
Xu M, Palmer AK, Ding H, Weivoda MM, Pirtskhalava T, White TA, Sepe A, Johnson KO, Stout MB, Giorgadze N, Jensen MD, LeBrasseur NK, Tchkonia T, Kirkland JL. Xu M, et al. Among authors: tchkonia t. Elife. 2015 Dec 19;4:e12997. doi: 10.7554/eLife.12997. Elife. 2015. PMID: 26687007 Free PMC article.
202 results