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Page 1
Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.
Chen L, Sung SS, Yip ML, Lawrence HR, Ren Y, Guida WC, Sebti SM, Lawrence NJ, Wu J. Chen L, et al. Among authors: lawrence nj, lawrence hr. Mol Pharmacol. 2006 Aug;70(2):562-70. doi: 10.1124/mol.106.025536. Epub 2006 May 22. Mol Pharmacol. 2006. PMID: 16717135
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.
Siddiquee K, Zhang S, Guida WC, Blaskovich MA, Greedy B, Lawrence HR, Yip ML, Jove R, McLaughlin MM, Lawrence NJ, Sebti SM, Turkson J. Siddiquee K, et al. Among authors: lawrence nj, lawrence hr. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7391-6. doi: 10.1073/pnas.0609757104. Epub 2007 Apr 26. Proc Natl Acad Sci U S A. 2007. PMID: 17463090 Free PMC article.
Targeting protein tyrosine phosphatases for anticancer drug discovery.
Scott LM, Lawrence HR, Sebti SM, Lawrence NJ, Wu J. Scott LM, et al. Among authors: lawrence nj, lawrence hr. Curr Pharm Des. 2010 Jun;16(16):1843-62. doi: 10.2174/138161210791209027. Curr Pharm Des. 2010. PMID: 20337577 Free PMC article. Review.
Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112.
Chen L, Pernazza D, Scott LM, Lawrence HR, Ren Y, Luo Y, Wu X, Sung SS, Guida WC, Sebti SM, Lawrence NJ, Wu J. Chen L, et al. Among authors: lawrence nj, lawrence hr. Biochem Pharmacol. 2010 Sep 15;80(6):801-10. doi: 10.1016/j.bcp.2010.05.019. Epub 2010 May 25. Biochem Pharmacol. 2010. PMID: 20510203 Free PMC article.
Abnormal MDMX degradation in tumor cells due to ARF deficiency.
Li X, Gilkes D, Li B, Cheng Q, Pernazza D, Lawrence H, Lawrence N, Chen J. Li X, et al. Oncogene. 2012 Aug 9;31(32):3721-32. doi: 10.1038/onc.2011.534. Epub 2011 Nov 28. Oncogene. 2012. PMID: 22120712 Free PMC article.
123 results