Hamel E - Search Results

1

Design, synthesis, and structure-activity relationships of pyrimido[4,5-b]indole-4-amines as microtubule depolymerizing agents that are effective against multidrug resistant cells.

Devambatla RKV, Li W, Zaware N, Choudhary S, Hamel E, Mooberry SL, Gangjee A. Devambatla RKV, et al. Among authors: hamel e. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3423-3430. doi: 10.1016/j.bmcl.2017.05.085. Epub 2017 May 27. Bioorg Med Chem Lett. 2017. PMID: 28610978 Free PMC article.

2

Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions.

Getahun Z, Jurd L, Chu PS, Lin CM, Hamel E. Getahun Z, et al. Among authors: hamel e. J Med Chem. 1992 Mar 20;35(6):1058-67. doi: 10.1021/jm00084a011. J Med Chem. 1992. PMID: 1552500

3

Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents.

Cushman M, Nagarathnam D, Gopal D, He HM, Lin CM, Hamel E. Cushman M, et al. Among authors: hamel e. J Med Chem. 1992 Jun 12;35(12):2293-306. doi: 10.1021/jm00090a021. J Med Chem. 1992. PMID: 1613753

4

Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids.

Muzaffar A, Brossi A, Lin CM, Hamel E. Muzaffar A, et al. Among authors: hamel e. J Med Chem. 1990 Feb;33(2):567-71. doi: 10.1021/jm00164a015. J Med Chem. 1990. PMID: 2299625

5

Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site.

Cushman M, He HM, Katzenellenbogen JA, Lin CM, Hamel E. Cushman M, et al. Among authors: hamel e. J Med Chem. 1995 Jun 9;38(12):2041-9. doi: 10.1021/jm00012a003. J Med Chem. 1995. PMID: 7783135

6

Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin.

Kuo SC, Lee HZ, Juang JP, Lin YT, Wu TS, Chang JJ, Lednicer D, Paull KD, Lin CM, Hamel E, et al. Kuo SC, et al. Among authors: hamel e. J Med Chem. 1993 Apr 30;36(9):1146-56. doi: 10.1021/jm00061a005. J Med Chem. 1993. PMID: 8387598

7

Synthesis and evaluation of a series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization.

Cushman M, He HM, Lin CM, Hamel E. Cushman M, et al. Among authors: hamel e. J Med Chem. 1993 Sep 17;36(19):2817-21. doi: 10.1021/jm00071a012. J Med Chem. 1993. PMID: 8410995

8

Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic agents.

Sun L, McPhail AT, Hamel E, Lin CM, Hastie SB, Chang JJ, Lee KH. Sun L, et al. Among authors: hamel e. J Med Chem. 1993 Mar 5;36(5):544-51. doi: 10.1021/jm00057a004. J Med Chem. 1993. PMID: 8496935

9

Computational and molecular modeling evaluation of the structural basis for tubulin polymerization inhibition by colchicine site agents.

ter Haar E, Rosenkranz HS, Hamel E, Day BW. ter Haar E, et al. Among authors: hamel e. Bioorg Med Chem. 1996 Oct;4(10):1659-71. doi: 10.1016/0968-0896(96)00158-7. Bioorg Med Chem. 1996. PMID: 8931935

10

Synthesis and biological evaluation of 1,1-dichloro-2,3-diarylcyclopropanes as antitubulin and anti-breast cancer agents.

Jonnalagadda SS, ter Haar E, Hamel E, Lin CM, Magarian RA, Day BW. Jonnalagadda SS, et al. Among authors: hamel e. Bioorg Med Chem. 1997 Apr;5(4):715-22. doi: 10.1016/s0968-0896(97)00014-x. Bioorg Med Chem. 1997. PMID: 9158870

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