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Design, synthesis, and structure-activity relationships of pyrimido[4,5-b]indole-4-amines as microtubule depolymerizing agents that are effective against multidrug resistant cells.
Devambatla RKV, Li W, Zaware N, Choudhary S, Hamel E, Mooberry SL, Gangjee A. Devambatla RKV, et al. Among authors: zaware n. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3423-3430. doi: 10.1016/j.bmcl.2017.05.085. Epub 2017 May 27. Bioorg Med Chem Lett. 2017. PMID: 28610978 Free PMC article.
Synthesis of N(4)-(substituted phenyl)-N(4)-alkyl/desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines and identification of new microtubule disrupting compounds that are effective against multidrug resistant cells.
Gangjee A, Zaware N, Devambatla RK, Raghavan S, Westbrook CD, Dybdal-Hargreaves NF, Hamel E, Mooberry SL. Gangjee A, et al. Among authors: zaware n. Bioorg Med Chem. 2013 Feb 15;21(4):891-902. doi: 10.1016/j.bmc.2012.12.010. Epub 2012 Dec 20. Bioorg Med Chem. 2013. PMID: 23332369 Free PMC article.
Synthesis and biological activity of 5-chloro-N⁴-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents.
Gangjee A, Zaware N, Raghavan S, Disch BC, Thorpe JE, Bastian A, Ihnat MA. Gangjee A, et al. Among authors: zaware n. Bioorg Med Chem. 2013 Apr 1;21(7):1857-64. doi: 10.1016/j.bmc.2013.01.040. Epub 2013 Jan 31. Bioorg Med Chem. 2013. PMID: 23434139 Free PMC article.
Reengineered tricyclic anti-cancer agents.
Kastrinsky DB, Sangodkar J, Zaware N, Izadmehr S, Dhawan NS, Narla G, Ohlmeyer M. Kastrinsky DB, et al. Among authors: zaware n. Bioorg Med Chem. 2015 Oct 1;23(19):6528-34. doi: 10.1016/j.bmc.2015.07.007. Epub 2015 Sep 11. Bioorg Med Chem. 2015. PMID: 26372073 Free PMC article.
22 results