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Cardiac overexpression of Epac1 in transgenic mice rescues lipopolysaccharide-induced cardiac dysfunction and inhibits Jak-STAT pathway.
Jin H, Fujita T, Jin M, Kurotani R, Namekata I, Hamaguchi S, Hidaka Y, Cai W, Suita K, Ohnuki Y, Mototani Y, Shiozawa K, Prajapati R, Liang C, Umemura M, Yokoyama U, Sato M, Tanaka H, Okumura S, Ishikawa Y. Jin H, et al. Among authors: jin m. J Mol Cell Cardiol. 2017 Jul;108:170-180. doi: 10.1016/j.yjmcc.2017.05.014. Epub 2017 Jun 16. J Mol Cell Cardiol. 2017. PMID: 28629760
Epac activation inhibits IL-6-induced cardiac myocyte dysfunction.
Jin H, Fujita T, Jin M, Kurotani R, Hidaka Y, Cai W, Suita K, Prajapati R, Liang C, Ohnuki Y, Mototani Y, Umemura M, Yokoyama U, Sato M, Okumura S, Ishikawa Y. Jin H, et al. Among authors: jin m. J Physiol Sci. 2018 Jan;68(1):77-87. doi: 10.1007/s12576-016-0509-5. Epub 2016 Dec 19. J Physiol Sci. 2018. PMID: 27995459 Free PMC article.
Correction to: Epac activation inhibits IL-6-induced cardiac myocyte dysfunction.
Jin H, Fujita T, Jin M, Kurotani R, Hidaka Y, Cai W, Suita K, Prajapati R, Liang C, Ohnuki Y, Mototani Y, Umemura M, Yokoyama U, Sato M, Okumura S, Ishikawa Y. Jin H, et al. Among authors: jin m. J Physiol Sci. 2019 May;69(3):557. doi: 10.1007/s12576-019-00661-0. J Physiol Sci. 2019. PMID: 30762213 Free PMC article.
Pharmacological stimulation of type 5 adenylyl cyclase stabilizes heart rate under both microgravity and hypergravity induced by parabolic flight.
Bai Y, Tsunematsu T, Jiao Q, Ohnuki Y, Mototani Y, Shiozawa K, Jin M, Cai W, Jin HL, Fujita T, Ichikawa Y, Suita K, Kurotani R, Yokoyama U, Sato M, Iwatsubo K, Ishikawa Y, Okumura S. Bai Y, et al. J Pharmacol Sci. 2012;119(4):381-9. doi: 10.1254/jphs.12102fp. Epub 2012 Jul 31. J Pharmacol Sci. 2012. PMID: 22850613 Free article.
Inhibition of EP4 signaling attenuates aortic aneurysm formation.
Yokoyama U, Ishiwata R, Jin MH, Kato Y, Suzuki O, Jin H, Ichikawa Y, Kumagaya S, Katayama Y, Fujita T, Okumura S, Sato M, Sugimoto Y, Aoki H, Suzuki S, Masuda M, Minamisawa S, Ishikawa Y. Yokoyama U, et al. Among authors: jin h, jin mh. PLoS One. 2012;7(5):e36724. doi: 10.1371/journal.pone.0036724. Epub 2012 May 3. PLoS One. 2012. PMID: 22570740 Free PMC article.
Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses.
Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin H, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, Ishikawa Y. Okumura S, et al. Among authors: jin h, jin m. J Clin Invest. 2014 Jun;124(6):2785-801. doi: 10.1172/JCI64784. Epub 2014 Apr 24. J Clin Invest. 2014. PMID: 24892712 Free PMC article.
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