Ory DS - Search Results

1

Analytical Characterization of Methyl-β-Cyclodextrin for Pharmacological Activity to Reduce Lysosomal Cholesterol Accumulation in Niemann-Pick Disease Type C1 Cells.

Li R, Hao J, Fujiwara H, Xu M, Yang S, Dai S, Long Y, Swaroop M, Li C, Vu M, Marugan JJ, Ory DS, Zheng W. Li R, et al. Among authors: ory ds. Assay Drug Dev Technol. 2017 May/Jun;15(4):154-166. doi: 10.1089/adt.2017.774. Assay Drug Dev Technol. 2017. PMID: 28631941 Free PMC article.

2

Niemann-pick type C1 (NPC1) overexpression alters cellular cholesterol homeostasis.

Millard EE, Srivastava K, Traub LM, Schaffer JE, Ory DS. Millard EE, et al. Among authors: ory ds. J Biol Chem. 2000 Dec 8;275(49):38445-51. doi: 10.1074/jbc.M003180200. J Biol Chem. 2000. PMID: 10964915 Free article.

3

Cholesterol overload promotes morphogenesis of a Niemann-Pick C (NPC)-like compartment independent of inhibition of NPC1 or HE1/NPC2 function.

Frolov A, Srivastava K, Daphna-Iken D, Traub LM, Schaffer JE, Ory DS. Frolov A, et al. Among authors: ory ds. J Biol Chem. 2001 Dec 7;276(49):46414-21. doi: 10.1074/jbc.M108099200. Epub 2001 Sep 24. J Biol Chem. 2001. PMID: 11571306 Free article.

4

The niemann-pick disease genes; regulators of cellular cholesterol homeostasis.

Ory DS. Ory DS. Trends Cardiovasc Med. 2004 Feb;14(2):66-72. doi: 10.1016/j.tcm.2003.12.003. Trends Cardiovasc Med. 2004. PMID: 15030792 Review.

5

The sterol-sensing domain of the Niemann-Pick C1 (NPC1) protein regulates trafficking of low density lipoprotein cholesterol.

Millard EE, Gale SE, Dudley N, Zhang J, Schaffer JE, Ory DS. Millard EE, et al. Among authors: ory ds. J Biol Chem. 2005 Aug 5;280(31):28581-90. doi: 10.1074/jbc.M414024200. Epub 2005 May 20. J Biol Chem. 2005. PMID: 15908696 Free article.

6

Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease.

Langmade SJ, Gale SE, Frolov A, Mohri I, Suzuki K, Mellon SH, Walkley SU, Covey DF, Schaffer JE, Ory DS. Langmade SJ, et al. Among authors: ory ds. Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13807-12. doi: 10.1073/pnas.0606218103. Epub 2006 Aug 29. Proc Natl Acad Sci U S A. 2006. PMID: 16940355 Free PMC article.

7

Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking.

Zhang JR, Coleman T, Langmade SJ, Scherrer DE, Lane L, Lanier MH, Feng C, Sands MS, Schaffer JE, Semenkovich CF, Ory DS. Zhang JR, et al. Among authors: ory ds. J Clin Invest. 2008 Jun;118(6):2281-90. doi: 10.1172/JCI32561. J Clin Invest. 2008. PMID: 18483620 Free PMC article.

8

Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease.

Porter FD, Scherrer DE, Lanier MH, Langmade SJ, Molugu V, Gale SE, Olzeski D, Sidhu R, Dietzen DJ, Fu R, Wassif CA, Yanjanin NM, Marso SP, House J, Vite C, Schaffer JE, Ory DS. Porter FD, et al. Among authors: ory ds. Sci Transl Med. 2010 Nov 3;2(56):56ra81. doi: 10.1126/scitranslmed.3001417. Sci Transl Med. 2010. PMID: 21048217 Free PMC article.

9

A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma.

Jiang X, Sidhu R, Porter FD, Yanjanin NM, Speak AO, te Vruchte DT, Platt FM, Fujiwara H, Scherrer DE, Zhang J, Dietzen DJ, Schaffer JE, Ory DS. Jiang X, et al. Among authors: ory ds. J Lipid Res. 2011 Jul;52(7):1435-45. doi: 10.1194/jlr.D015735. Epub 2011 Apr 24. J Lipid Res. 2011. PMID: 21518695 Free PMC article.

10

Microarray expression analysis and identification of serum biomarkers for Niemann-Pick disease, type C1.

Cluzeau CV, Watkins-Chow DE, Fu R, Borate B, Yanjanin N, Dail MK, Davidson CD, Walkley SU, Ory DS, Wassif CA, Pavan WJ, Porter FD. Cluzeau CV, et al. Among authors: ory ds. Hum Mol Genet. 2012 Aug 15;21(16):3632-46. doi: 10.1093/hmg/dds193. Epub 2012 May 22. Hum Mol Genet. 2012. PMID: 22619379 Free PMC article.

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