Chen X - Search Results

1

Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson's disease.

Fang F, Yang W, Florio JB, Rockenstein E, Spencer B, Orain XM, Dong SX, Li H, Chen X, Sung K, Rissman RA, Masliah E, Ding J, Wu C. Fang F, et al. Among authors: chen x. Sci Rep. 2017 Jun 20;7(1):3868. doi: 10.1038/s41598-017-04232-4. Sci Rep. 2017. PMID: 28634349 Free PMC article.

2

Endosome-mediated retrograde axonal transport of P2X3 receptor signals in primary sensory neurons.

Chen XQ, Wang B, Wu C, Pan J, Yuan B, Su YY, Jiang XY, Zhang X, Bao L. Chen XQ, et al. Cell Res. 2012 Apr;22(4):677-96. doi: 10.1038/cr.2011.197. Epub 2011 Dec 13. Cell Res. 2012. PMID: 22157653 Free PMC article.

3

TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease.

Zhao X, Chen XQ, Han E, Hu Y, Paik P, Ding Z, Overman J, Lau AL, Shahmoradian SH, Chiu W, Thompson LM, Wu C, Mobley WC. Zhao X, et al. Among authors: chen xq. Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5655-64. doi: 10.1073/pnas.1603020113. Epub 2016 Sep 6. Proc Natl Acad Sci U S A. 2016. PMID: 27601642 Free PMC article.

4

Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy.

Mo Z, Zhao X, Liu H, Hu Q, Chen XQ, Pham J, Wei N, Liu Z, Zhou J, Burgess RW, Pfaff SL, Caskey CT, Wu C, Bai G, Yang XL. Mo Z, et al. Among authors: chen xq. Nat Commun. 2018 Mar 8;9(1):1007. doi: 10.1038/s41467-018-03461-z. Nat Commun. 2018. PMID: 29520015 Free PMC article.

5

T-complex protein 1-ring complex enhances retrograde axonal transport by modulating tau phosphorylation.

Chen XQ, Fang F, Florio JB, Rockenstein E, Masliah E, Mobley WC, Rissman RA, Wu C. Chen XQ, et al. Traffic. 2018 Nov;19(11):840-853. doi: 10.1111/tra.12610. Epub 2018 Sep 12. Traffic. 2018. PMID: 30120810 Free PMC article.

6

BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's disease.

Gu Y, Pope A, Smith C, Carmona C, Johnstone A, Shi L, Chen X, Santos S, Bacon-Brenes CC, Shoff T, Kleczko KM, Frydman J, Thompson LM, Mobley WC, Wu C. Gu Y, et al. Among authors: chen x. Neurobiol Dis. 2024 Jun 1;195:106502. doi: 10.1016/j.nbd.2024.106502. Epub 2024 Apr 10. Neurobiol Dis. 2024. PMID: 38608784 Free article.

7

Dysregulation of neurotrophin signaling in the pathogenesis of Alzheimer disease and of Alzheimer disease in Down syndrome.

Chen XQ, Sawa M, Mobley WC. Chen XQ, et al. Free Radic Biol Med. 2018 Jan;114:52-61. doi: 10.1016/j.freeradbiomed.2017.10.341. Epub 2017 Oct 12. Free Radic Biol Med. 2018. PMID: 29031834 Free PMC article. Review.

8

Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model.

Chen XQ, Salehi A, Pearn ML, Overk C, Nguyen PD, Kleschevnikov AM, Maccecchini M, Mobley WC. Chen XQ, et al. Alzheimers Dement. 2021 Feb;17(2):271-292. doi: 10.1002/alz.12185. Epub 2020 Sep 25. Alzheimers Dement. 2021. PMID: 32975365 Free PMC article.

9

Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport.

Chen XQ, Das U, Park G, Mobley WC. Chen XQ, et al. Alzheimers Res Ther. 2021 Mar 10;13(1):59. doi: 10.1186/s13195-021-00796-6. Alzheimers Res Ther. 2021. PMID: 33691783 Free PMC article.

10

Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose.

Chen XQ, Zuo X, Becker A, Head E, Mobley WC. Chen XQ, et al. Alzheimers Dement. 2023 May;19(5):2095-2116. doi: 10.1002/alz.12835. Epub 2022 Nov 12. Alzheimers Dement. 2023. PMID: 36370135 Free PMC article.

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