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The tRNA discriminator base defines the mutual orthogonality of two distinct pyrrolysyl-tRNA synthetase/tRNAPyl pairs in the same organism.
Zhang H, Gong X, Zhao Q, Mukai T, Vargas-Rodriguez O, Zhang H, Zhang Y, Wassel P, Amikura K, Maupin-Furlow J, Ren Y, Xu X, Wolf YI, Makarova KS, Koonin EV, Shen Y, Söll D, Fu X. Zhang H, et al. Nucleic Acids Res. 2022 May 6;50(8):4601-4615. doi: 10.1093/nar/gkac271. Nucleic Acids Res. 2022. PMID: 35466371 Free PMC article.