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Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats.
Liu Y, Richardson J, Tran T, Al-Muhtasib N, Xie T, Yenugonda VM, Sexton HG, Rezvani AH, Levin ED, Sahibzada N, Kellar KJ, Brown ML, Xiao Y, Paige M. Liu Y, et al. Among authors: sahibzada n. J Med Chem. 2013 Apr 11;56(7):3000-11. doi: 10.1021/jm4000374. Epub 2013 Apr 1. J Med Chem. 2013. PMID: 23540678 Free PMC article.
Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands.
Yenugonda VM, Xiao Y, Levin ED, Rezvani AH, Tran T, Al-Muhtasib N, Sahibzada N, Xie T, Wells C, Slade S, Johnson JE, Dakshanamurthy S, Kong HS, Tomita Y, Liu Y, Paige M, Kellar KJ, Brown ML. Yenugonda VM, et al. Among authors: sahibzada n. J Med Chem. 2013 Nov 14;56(21):8404-21. doi: 10.1021/jm4008455. Epub 2013 Oct 18. J Med Chem. 2013. PMID: 24047231
Chronic sazetidine-A maintains anxiolytic effects and slower weight gain following chronic nicotine without maintaining increased density of nicotinic receptors in rodent brain.
Hussmann GP, DeDominicis KE, Turner JR, Yasuda RP, Klehm J, Forcelli PA, Xiao Y, Richardson JR, Sahibzada N, Wolfe BB, Lindstrom J, Blendy JA, Kellar KJ. Hussmann GP, et al. Among authors: sahibzada n. J Neurochem. 2014 May;129(4):721-31. doi: 10.1111/jnc.12653. Epub 2014 Feb 7. J Neurochem. 2014. PMID: 24422997 Free PMC article.
55 results