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Application of hydrazino and hydrazido linkers to connect benzenesulfonamides with hydrophilic/phobic tails for targeting the middle region of human carbonic anhydrases active site: Selective inhibitors of hCA IX.
Allam HA, Fahim SH, F Abo-Ashour M, Nocentini A, Elbakry ME, Abdelrahman MA, Eldehna WM, Ibrahim HS, Supuran CT. Allam HA, et al. Among authors: abdelrahman ma. Eur J Med Chem. 2019 Oct 1;179:547-556. doi: 10.1016/j.ejmech.2019.06.081. Epub 2019 Jun 28. Eur J Med Chem. 2019. PMID: 31276899
Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms.
Eldehna WM, Taghour MS, Al-Warhi T, Nocentini A, Elbadawi MM, Mahdy HA, Abdelrahman MA, Alotaibi OJ, Aljaeed N, Elimam DM, Afarinkia K, Abdel-Aziz HA, Supuran CT. Eldehna WM, et al. Among authors: abdelrahman ma. J Enzyme Inhib Med Chem. 2022 Dec;37(1):531-541. doi: 10.1080/14756366.2021.2024528. J Enzyme Inhib Med Chem. 2022. PMID: 34991416 Free PMC article.
Synthesis, biological evaluation and in silico studies with 4-benzylidene-2-phenyl-5(4H)-imidazolone-based benzenesulfonamides as novel selective carbonic anhydrase IX inhibitors endowed with anticancer activity.
Eldehna WM, Abdelrahman MA, Nocentini A, Bua S, Al-Rashood ST, Hassan GS, Bonardi A, Almehizia AA, Alkahtani HM, Alharbi A, Gratteri P, Supuran CT. Eldehna WM, et al. Among authors: abdelrahman ma. Bioorg Chem. 2019 Sep;90:103102. doi: 10.1016/j.bioorg.2019.103102. Epub 2019 Jul 2. Bioorg Chem. 2019. PMID: 31299596
Novel Diamide-Based Benzenesulfonamides as Selective Carbonic Anhydrase IX Inhibitors Endowed with Antitumor Activity: Synthesis, Biological Evaluation and In Silico Insights.
Abdelrahman MA, Eldehna WM, Nocentini A, Bua S, Al-Rashood ST, Hassan GS, Bonardi A, Almehizia AA, Alkahtani HM, Alharbi A, Gratteri P, Supuran CT. Abdelrahman MA, et al. Int J Mol Sci. 2019 May 20;20(10):2484. doi: 10.3390/ijms20102484. Int J Mol Sci. 2019. PMID: 31137489 Free PMC article.
169 results