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Page 1
Thrombin promotes diet-induced obesity through fibrin-driven inflammation.
Kopec AK, Abrahams SR, Thornton S, Palumbo JS, Mullins ES, Divanovic S, Weiler H, Owens AP 3rd, Mackman N, Goss A, van Ryn J, Luyendyk JP, Flick MJ. Kopec AK, et al. Among authors: abrahams sr. J Clin Invest. 2017 Aug 1;127(8):3152-3166. doi: 10.1172/JCI92744. Epub 2017 Jul 24. J Clin Invest. 2017. PMID: 28737512 Free PMC article.
Fibrin(ogen) engagement of S. aureus promotes the host antimicrobial response and suppression of microbe dissemination following peritoneal infection.
Negrón O, Hur WS, Prasad J, Paul DS, Rowe SE, Degen JL, Abrahams SR, Antoniak S, Conlon BP, Bergmeier W, Hӧӧk M, Flick MJ. Negrón O, et al. Among authors: abrahams sr. PLoS Pathog. 2022 Jan 18;18(1):e1010227. doi: 10.1371/journal.ppat.1010227. eCollection 2022 Jan. PLoS Pathog. 2022. PMID: 35041705 Free PMC article.
Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A.
Strilchuk AW, Hur WS, Batty P, Sang Y, Abrahams SR, Yong ASM, Leung J, Silva LM, Schroeder JA, Nesbitt K, de Laat B, Moutsopoulos NM, Bugge TH, Shi Q, Cullis PR, Merricks EP, Wolberg AS, Flick MJ, Lillicrap D, Nichols TC, Kastrup CJ. Strilchuk AW, et al. Among authors: abrahams sr. Sci Transl Med. 2024 Feb 21;16(735):eadh0027. doi: 10.1126/scitranslmed.adh0027. Epub 2024 Feb 21. Sci Transl Med. 2024. PMID: 38381848 Free PMC article.
Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression.
Chowdhury NN, Yang Y, Dutta A, Luo M, Wei Z, Abrahams SR, Revenko AS, Shah F, Miles LA, Parmer RJ, de Laat B, Wolberg AS, Luyendyk JP, Fishel ML, Flick MJ. Chowdhury NN, et al. Among authors: abrahams sr. Mol Oncol. 2024 Jan;18(1):113-135. doi: 10.1002/1878-0261.13552. Epub 2023 Nov 27. Mol Oncol. 2024. PMID: 37971174 Free PMC article.