Burke TR Jr - Search Results

1

Targeted sulfur(VI) fluoride exchange-mediated covalent modification of a tyrosine residue in the catalytic pocket of tyrosyl-DNA phosphodiesterase 1.

Zhao XZ, Barakat IA, Lountos GT, Wang W, Agama K, Mahmud MRA, Suazo KF, Andresson T, Pommier Y, Burke TR Jr. Zhao XZ, et al. Among authors: burke tr jr. Commun Chem. 2024 Sep 16;7(1):208. doi: 10.1038/s42004-024-01298-w. Commun Chem. 2024. PMID: 39284936 Free PMC article.

2

Affinity enhancement of polo-like kinase 1 polo box domain-binding ligands by a bivalent approach using a covalent kinase-binding component.

Tsuji K, Tamamura H, Burke TR Jr. Tsuji K, et al. Among authors: burke tr jr. RSC Chem Biol. 2024 Jun 4;5(8):721-728. doi: 10.1039/d4cb00031e. eCollection 2024 Jul 31. RSC Chem Biol. 2024. PMID: 39092437 Free PMC article.

3

Application of a Fluorescence Recovery-Based Polo-Like Kinase 1 Binding Assay to Polo-Like Kinase 2 and Polo-Like Kinase 3.

Tsuji K, Tamamura H, Burke TR Jr. Tsuji K, et al. Among authors: burke tr jr. Biol Pharm Bull. 2024;47(7):1282-1287. doi: 10.1248/bpb.b24-00189. Biol Pharm Bull. 2024. PMID: 38987177 Free article.

4

Enhancing precision in colorectal cancer surgery: development of an LGR5-targeting RSPO1 peptide mimetic as a contrast agent for intraoperative fluorescence molecular imaging.

Parasido E, Ribeiro P, Chingle RM, Rohwetter T, Gupta N, Avetian G, Bladelli E, Pierobon M, Chen Y, Tang Q, Schnermann M, Rodriguez O, Robbins D, Burke TR Jr, Albanese C, Ihemelandu C. Parasido E, et al. Among authors: burke tr jr. Cell Cycle. 2024 Jul 10:1-12. doi: 10.1080/15384101.2024.2364578. Online ahead of print. Cell Cycle. 2024. PMID: 38984667

5

N-Substituted Bicyclic Carbamoyl Pyridones: Integrase Strand Transfer Inhibitors that Potently Inhibit Drug-Resistant HIV-1 Integrase Mutants.

Mahajan PS, Smith SJ, Li M, Craigie R, Hughes SH, Zhao XZ, Burke TR Jr. Mahajan PS, et al. Among authors: burke tr jr. ACS Infect Dis. 2024 Mar 8;10(3):917-927. doi: 10.1021/acsinfecdis.3c00525. Epub 2024 Feb 12. ACS Infect Dis. 2024. PMID: 38346249 Free PMC article.

6

Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.

Li M, Oliveira Passos D, Shan Z, Smith SJ, Sun Q, Biswas A, Choudhuri I, Strutzenberg TS, Haldane A, Deng N, Li Z, Zhao XZ, Briganti L, Kvaratskhelia M, Burke TR Jr, Levy RM, Hughes SH, Craigie R, Lyumkis D. Li M, et al. Among authors: burke tr jr. Sci Adv. 2023 Jul 21;9(29):eadg5953. doi: 10.1126/sciadv.adg5953. Epub 2023 Jul 21. Sci Adv. 2023. PMID: 37478179 Free article.

7

Synthetic Approaches to a Key Pyridone-carboxylic Acid Precursor Common to the HIV-1 Integrase Strand Transfer Inhibitors Dolutegravir, Bictegravir, and Cabotegravir.

Mahajan PS, Burke TR Jr. Mahajan PS, et al. Among authors: burke tr jr. Org Process Res Dev. 2023 Apr 20;27(5):847-853. doi: 10.1021/acs.oprd.3c00063. eCollection 2023 May 19. Org Process Res Dev. 2023. PMID: 37229216 Free PMC article. Review.

8

Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification.

Zhao XZ, Wang W, Lountos GT, Kiselev E, Tropea JE, Needle D, Pommier Y, Burke TR Jr. Zhao XZ, et al. Among authors: burke tr jr. RSC Chem Biol. 2023 Mar 27;4(5):334-343. doi: 10.1039/d2cb00230b. eCollection 2023 May 10. RSC Chem Biol. 2023. PMID: 37181631 Free PMC article.

9

A Practical Approach to Bicyclic Carbamoyl Pyridones with Application to the Synthesis of HIV-1 Integrase Strand Transfer Inhibitors.

Mahajan PS, Smith SJ, Hughes SH, Zhao X, Burke TR Jr. Mahajan PS, et al. Among authors: burke tr jr. Molecules. 2023 Feb 2;28(3):1428. doi: 10.3390/molecules28031428. Molecules. 2023. PMID: 36771093 Free PMC article.

10

Development of ultra-high affinity bivalent ligands targeting the polo-like kinase 1.

Tsuji K, Hymel D, Ma B, Tamamura H, Nussinov R, Burke TR Jr. Tsuji K, et al. Among authors: burke tr jr. RSC Chem Biol. 2022 Jul 15;3(9):1111-1120. doi: 10.1039/d2cb00153e. eCollection 2022 Aug 31. RSC Chem Biol. 2022. PMID: 36128509 Free PMC article.

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