Ramdzan YM - Search Results

1

Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways.

Moily NS, Ormsby AR, Stojilovic A, Ramdzan YM, Diesch J, Hannan RD, Zajac MS, Hannan AJ, Oshlack A, Hatters DM. Moily NS, et al. Among authors: ramdzan ym. Mol Cell Neurosci. 2017 Sep;83:103-112. doi: 10.1016/j.mcn.2017.07.004. Epub 2017 Jul 23. Mol Cell Neurosci. 2017. PMID: 28743452

2

Tracking protein aggregation and mislocalization in cells with flow cytometry.

Ramdzan YM, Polling S, Chia CP, Ng IH, Ormsby AR, Croft NP, Purcell AW, Bogoyevitch MA, Ng DC, Gleeson PA, Hatters DM. Ramdzan YM, et al. Nat Methods. 2012 Mar 18;9(5):467-70. doi: 10.1038/nmeth.1930. Nat Methods. 2012. PMID: 22426490

3

A platform to view huntingtin exon 1 aggregation flux in the cell reveals divergent influences from chaperones hsp40 and hsp70.

Ormsby AR, Ramdzan YM, Mok YF, Jovanoski KD, Hatters DM. Ormsby AR, et al. Among authors: ramdzan ym. J Biol Chem. 2013 Dec 27;288(52):37192-203. doi: 10.1074/jbc.M113.486944. Epub 2013 Nov 6. J Biol Chem. 2013. PMID: 24196953 Free PMC article.

4

Tadpole-like Conformations of Huntingtin Exon 1 Are Characterized by Conformational Heterogeneity that Persists regardless of Polyglutamine Length.

Newcombe EA, Ruff KM, Sethi A, Ormsby AR, Ramdzan YM, Fox A, Purcell AW, Gooley PR, Pappu RV, Hatters DM. Newcombe EA, et al. Among authors: ramdzan ym. J Mol Biol. 2018 May 11;430(10):1442-1458. doi: 10.1016/j.jmb.2018.03.031. Epub 2018 Apr 5. J Mol Biol. 2018. PMID: 29627459 Free PMC article.

5

Conformation sensors that distinguish monomeric proteins from oligomers in live cells.

Ramdzan YM, Nisbet RM, Miller J, Finkbeiner S, Hill AF, Hatters DM. Ramdzan YM, et al. Chem Biol. 2010 Apr 23;17(4):371-9. doi: 10.1016/j.chembiol.2010.03.011. Chem Biol. 2010. PMID: 20416508 Free PMC article.

6

Tracking mutant huntingtin aggregation kinetics in cells reveals three major populations that include an invariant oligomer pool.

Olshina MA, Angley LM, Ramdzan YM, Tang J, Bailey MF, Hill AF, Hatters DM. Olshina MA, et al. Among authors: ramdzan ym. J Biol Chem. 2010 Jul 9;285(28):21807-16. doi: 10.1074/jbc.M109.084434. Epub 2010 May 5. J Biol Chem. 2010. PMID: 20444706 Free PMC article.

7

Pulse shape analysis (PulSA) to track protein translocalization in cells by flow cytometry: applications for polyglutamine aggregation.

Ramdzan YM, Wood R, Hatters DM. Ramdzan YM, et al. Methods Mol Biol. 2013;1017:85-93. doi: 10.1007/978-1-62703-438-8_6. Methods Mol Biol. 2013. PMID: 23719909

8

Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell.

Polling S, Mok YF, Ramdzan YM, Turner BJ, Yerbury JJ, Hill AF, Hatters DM. Polling S, et al. Among authors: ramdzan ym. J Biol Chem. 2014 Mar 7;289(10):6669-6680. doi: 10.1074/jbc.M113.520189. Epub 2014 Jan 14. J Biol Chem. 2014. PMID: 24425868 Free PMC article.

9

Application of flow cytometry to analyze intracellular location and trafficking of cargo in cell populations.

Toh WH, Houghton FJ, Chia PZ, Ramdzan YM, Hatters DM, Gleeson PA. Toh WH, et al. Among authors: ramdzan ym. Methods Mol Biol. 2015;1270:227-38. doi: 10.1007/978-1-4939-2309-0_17. Methods Mol Biol. 2015. PMID: 25702121

10

Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis.

Ramdzan YM, Trubetskov MM, Ormsby AR, Newcombe EA, Sui X, Tobin MJ, Bongiovanni MN, Gras SL, Dewson G, Miller JML, Finkbeiner S, Moily NS, Niclis J, Parish CL, Purcell AW, Baker MJ, Wilce JA, Waris S, Stojanovski D, Böcking T, Ang CS, Ascher DB, Reid GE, Hatters DM. Ramdzan YM, et al. Cell Rep. 2017 May 2;19(5):919-927. doi: 10.1016/j.celrep.2017.04.029. Cell Rep. 2017. PMID: 28467905 Free article.

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