Higgins JW - Search Results

1

Prediction of Transporter-Mediated Drug-Drug Interactions for Baricitinib.

Posada MM, Cannady EA, Payne CD, Zhang X, Bacon JA, Pak YA, Higgins JW, Shahri N, Hall SD, Hillgren KM. Posada MM, et al. Among authors: higgins jw. Clin Transl Sci. 2017 Nov;10(6):509-519. doi: 10.1111/cts.12486. Epub 2017 Jul 27. Clin Transl Sci. 2017. PMID: 28749581 Free PMC article. Clinical Trial.

2

Prediction of renal transporter mediated drug-drug interactions for pemetrexed using physiologically based pharmacokinetic modeling.

Posada MM, Bacon JA, Schneck KB, Tirona RG, Kim RB, Higgins JW, Pak YA, Hall SD, Hillgren KM. Posada MM, et al. Among authors: higgins jw. Drug Metab Dispos. 2015 Mar;43(3):325-34. doi: 10.1124/dmd.114.059618. Epub 2014 Dec 12. Drug Metab Dispos. 2015. PMID: 25504564

3

Itraconazole and clarithromycin as ketoconazole alternatives for clinical CYP3A inhibition studies.

Ke AB, Zamek-Gliszczynski MJ, Higgins JW, Hall SD. Ke AB, et al. Among authors: higgins jw. Clin Pharmacol Ther. 2014 May;95(5):473-6. doi: 10.1038/clpt.2014.41. Clin Pharmacol Ther. 2014. PMID: 24747234

4

Ablation of both organic cation transporter (OCT)1 and OCT2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics.

Higgins JW, Bedwell DW, Zamek-Gliszczynski MJ. Higgins JW, et al. Drug Metab Dispos. 2012 Jun;40(6):1170-7. doi: 10.1124/dmd.112.044875. Epub 2012 Mar 9. Drug Metab Dispos. 2012. PMID: 22407892

5

Utility of Oatp1a/1b-knockout and OATP1B1/3-humanized mice in the study of OATP-mediated pharmacokinetics and tissue distribution: case studies with pravastatin, atorvastatin, simvastatin, and carboxydichlorofluorescein.

Higgins JW, Bao JQ, Ke AB, Manro JR, Fallon JK, Smith PC, Zamek-Gliszczynski MJ. Higgins JW, et al. Drug Metab Dispos. 2014 Jan;42(1):182-92. doi: 10.1124/dmd.113.054783. Epub 2013 Nov 5. Drug Metab Dispos. 2014. PMID: 24194513

6

Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics.

Zamek-Gliszczynski MJ, Bedwell DW, Bao JQ, Higgins JW. Zamek-Gliszczynski MJ, et al. Among authors: higgins jw. Drug Metab Dispos. 2012 Sep;40(9):1825-33. doi: 10.1124/dmd.112.046508. Epub 2012 Jun 18. Drug Metab Dispos. 2012. PMID: 22711747

7

Clinical CYP3A inhibitor alternatives to ketoconazole, clarithromycin and itraconazole, are not transported into the liver by hepatic organic anion transporting polypeptides and organic cation transporter 1.

Higgins JW, Ke AB, Zamek-Gliszczynski MJ. Higgins JW, et al. Drug Metab Dispos. 2014 Nov;42(11):1780-4. doi: 10.1124/dmd.114.058784. Epub 2014 Aug 8. Drug Metab Dispos. 2014. PMID: 25106415

8

Metformin sinusoidal efflux from the liver is consistent with negligible biliary excretion and absence of enterohepatic cycling.

Zamek-Gliszczynski MJ, Bao JQ, Day JS, Higgins JW. Zamek-Gliszczynski MJ, et al. Among authors: higgins jw. Drug Metab Dispos. 2013 Nov;41(11):1967-71. doi: 10.1124/dmd.113.053025. Epub 2013 Sep 5. Drug Metab Dispos. 2013. PMID: 24009308

9

Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human.

Coe KJ, Feinstein M, Higgins JW, Leung P, Scott BP, Skaptason J, Tam Y, Volak LP, Kinong J, Bittner A, McAllister H, Lim NM, Hack M, Koudriakova T. Coe KJ, et al. Among authors: higgins jw. Drug Metab Dispos. 2022 Aug;50(8):1064-1076. doi: 10.1124/dmd.121.000825. Epub 2022 Jun 9. Drug Metab Dispos. 2022. PMID: 35680134

10

Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation.

Lawlor KT, Vanslambrouck JM, Higgins JW, Chambon A, Bishard K, Arndt D, Er PX, Wilson SB, Howden SE, Tan KS, Li F, Hale LJ, Shepherd B, Pentoney S, Presnell SC, Chen AE, Little MH. Lawlor KT, et al. Among authors: higgins jw. Nat Mater. 2021 Feb;20(2):260-271. doi: 10.1038/s41563-020-00853-9. Epub 2020 Nov 23. Nat Mater. 2021. PMID: 33230326 Free PMC article.

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