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Chronic hyperglycemia impairs insulin secretion by affecting insulin receptor expression, splicing, and signaling in RIN beta cell line and human islets of Langerhans.
Hribal ML, Perego L, Lovari S, Andreozzi F, Menghini R, Perego C, Finzi G, Usellini L, Placidi C, Capella C, Guzzi V, Lauro D, Bertuzzi F, Davalli A, Pozza G, Pontiroli A, Federici M, Lauro R, Brunetti A, Folli F, Sesti G. Hribal ML, et al. Among authors: federici m. FASEB J. 2003 Jul;17(10):1340-2. doi: 10.1096/fj.02-0685fje. Epub 2003 May 8. FASEB J. 2003. PMID: 12738810
Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha.
Federici M, Hribal ML, Menghini R, Kanno H, Marchetti V, Porzio O, Sunnarborg SW, Rizza S, Serino M, Cunsolo V, Lauro D, Mauriello A, Smookler DS, Sbraccia P, Sesti G, Lee DC, Khokha R, Accili D, Lauro R. Federici M, et al. J Clin Invest. 2005 Dec;115(12):3494-505. doi: 10.1172/JCI26052. Epub 2005 Nov 17. J Clin Invest. 2005. PMID: 16294222 Free PMC article.
461 results