Flaherty E - Search Results

1

Evaluating Synthetic Activation and Repression of Neuropsychiatric-Related Genes in hiPSC-Derived NPCs, Neurons, and Astrocytes.

Ho SM, Hartley BJ, Flaherty E, Rajarajan P, Abdelaal R, Obiorah I, Barretto N, Muhammad H, Phatnani HP, Akbarian S, Brennand KJ. Ho SM, et al. Among authors: flaherty e. Stem Cell Reports. 2017 Aug 8;9(2):615-628. doi: 10.1016/j.stemcr.2017.06.012. Epub 2017 Jul 27. Stem Cell Reports. 2017. PMID: 28757163 Free PMC article.

2

Increased abundance of translation machinery in stem cell-derived neural progenitor cells from four schizophrenia patients.

Topol A, English JA, Flaherty E, Rajarajan P, Hartley BJ, Gupta S, Desland F, Zhu S, Goff T, Friedman L, Rapoport J, Felsenfeld D, Cagney G, Mackay-Sim A, Savas JN, Aronow B, Fang G, Zhang B, Cotter D, Brennand KJ. Topol A, et al. Among authors: flaherty e. Transl Psychiatry. 2015 Oct 20;5(10):e662. doi: 10.1038/tp.2015.118. Transl Psychiatry. 2015. PMID: 26485546 Free PMC article.

3

Using hiPSCs to model neuropsychiatric copy number variations (CNVs) has potential to reveal underlying disease mechanisms.

Flaherty EK, Brennand KJ. Flaherty EK, et al. Brain Res. 2017 Jan 15;1655:283-293. doi: 10.1016/j.brainres.2015.11.009. Epub 2015 Nov 12. Brain Res. 2017. PMID: 26581337 Free PMC article. Review.

4

Patient-derived hiPSC neurons with heterozygous CNTNAP2 deletions display altered neuronal gene expression and network activity.

Flaherty E, Deranieh RM, Artimovich E, Lee IS, Siegel AJ, Levy DL, Nestor MW, Brennand KJ. Flaherty E, et al. NPJ Schizophr. 2017 Oct 2;3(1):35. doi: 10.1038/s41537-017-0033-5. NPJ Schizophr. 2017. PMID: 28970473 Free PMC article.

5

THC Treatment Alters Glutamate Receptor Gene Expression in Human Stem Cell-Derived Neurons.

Obiorah IV, Muhammad H, Stafford K, Flaherty EK, Brennand KJ. Obiorah IV, et al. Mol Neuropsychiatry. 2017 Nov;3(2):73-84. doi: 10.1159/000477762. Epub 2017 Jul 20. Mol Neuropsychiatry. 2017. PMID: 29230395 Free PMC article.

6

Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains.

Hoffman GE, Hartley BJ, Flaherty E, Ladran I, Gochman P, Ruderfer DM, Stahl EA, Rapoport J, Sklar P, Brennand KJ. Hoffman GE, et al. Among authors: flaherty e. Nat Commun. 2017 Dec 20;8(1):2225. doi: 10.1038/s41467-017-02330-5. Nat Commun. 2017. PMID: 29263384 Free PMC article.

7

New considerations for hiPSC-based models of neuropsychiatric disorders.

Hoffman GE, Schrode N, Flaherty E, Brennand KJ. Hoffman GE, et al. Among authors: flaherty e. Mol Psychiatry. 2019 Jan;24(1):49-66. doi: 10.1038/s41380-018-0029-1. Epub 2018 Feb 26. Mol Psychiatry. 2019. PMID: 29483625 Free PMC article. Review.

8

Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk.

Rajarajan P, Borrman T, Liao W, Schrode N, Flaherty E, Casiño C, Powell S, Yashaswini C, LaMarca EA, Kassim B, Javidfar B, Espeso-Gil S, Li A, Won H, Geschwind DH, Ho SM, MacDonald M, Hoffman GE, Roussos P, Zhang B, Hahn CG, Weng Z, Brennand KJ, Akbarian S. Rajarajan P, et al. Among authors: flaherty e. Science. 2018 Dec 14;362(6420):eaat4311. doi: 10.1126/science.aat4311. Science. 2018. PMID: 30545851 Free PMC article.

9

CRISPR-based functional evaluation of schizophrenia risk variants.

Rajarajan P, Flaherty E, Akbarian S, Brennand KJ. Rajarajan P, et al. Among authors: flaherty e. Schizophr Res. 2020 Mar;217:26-36. doi: 10.1016/j.schres.2019.06.017. Epub 2019 Jul 3. Schizophr Res. 2020. PMID: 31277978 Free PMC article.

10

Synergistic effects of common schizophrenia risk variants.

Schrode N, Ho SM, Yamamuro K, Dobbyn A, Huckins L, Matos MR, Cheng E, Deans PJM, Flaherty E, Barretto N, Topol A, Alganem K, Abadali S, Gregory J, Hoelzli E, Phatnani H, Singh V, Girish D, Aronow B, Mccullumsmith R, Hoffman GE, Stahl EA, Morishita H, Sklar P, Brennand KJ. Schrode N, et al. Among authors: flaherty e. Nat Genet. 2019 Oct;51(10):1475-1485. doi: 10.1038/s41588-019-0497-5. Epub 2019 Sep 23. Nat Genet. 2019. PMID: 31548722 Free PMC article.

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