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Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6.
Ohkura SI, Usui S, Takashima SI, Takuwa N, Yoshioka K, Okamoto Y, Inagaki Y, Sugimoto N, Kitano T, Takamura M, Wada T, Kaneko S, Takuwa Y. Ohkura SI, et al. Among authors: okamoto y. PLoS One. 2017 Aug 3;12(8):e0182329. doi: 10.1371/journal.pone.0182329. eCollection 2017. PLoS One. 2017. PMID: 28771545 Free PMC article.
S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species.
Takuwa N, Ohkura S, Takashima S, Ohtani K, Okamoto Y, Tanaka T, Hirano K, Usui S, Wang F, Du W, Yoshioka K, Banno Y, Sasaki M, Ichi I, Okamura M, Sugimoto N, Mizugishi K, Nakanuma Y, Ishii I, Takamura M, Kaneko S, Kojo S, Satouchi K, Mitumori K, Chun J, Takuwa Y. Takuwa N, et al. Among authors: okamoto y. Cardiovasc Res. 2010 Feb 1;85(3):484-93. doi: 10.1093/cvr/cvp312. Epub 2009 Sep 15. Cardiovasc Res. 2010. PMID: 19755413 Free PMC article.
Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice.
Qi X, Okamoto Y, Murakawa T, Wang F, Oyama O, Ohkawa R, Yoshioka K, Du W, Sugimoto N, Yatomi Y, Takuwa N, Takuwa Y. Qi X, et al. Among authors: okamoto y. Eur J Pharmacol. 2010 May 25;634(1-3):121-31. doi: 10.1016/j.ejphar.2010.02.038. Epub 2010 Mar 3. Eur J Pharmacol. 2010. PMID: 20206620 Free article.
Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice.
Wang F, Okamoto Y, Inoki I, Yoshioka K, Du W, Qi X, Takuwa N, Gonda K, Yamamoto Y, Ohkawa R, Nishiuchi T, Sugimoto N, Yatomi Y, Mitsumori K, Asano M, Kinoshita M, Takuwa Y. Wang F, et al. Among authors: okamoto y. J Clin Invest. 2010 Nov;120(11):3979-95. doi: 10.1172/JCI42315. Epub 2010 Oct 18. J Clin Invest. 2010. Retraction in: J Clin Invest. 2012 Mar;122(3):1131. doi: 10.1172/jci63366 PMID: 20978351 Free PMC article. Retracted.
Roles of sphingosine-1-phosphate signaling in angiogenesis.
Takuwa Y, Du W, Qi X, Okamoto Y, Takuwa N, Yoshioka K. Takuwa Y, et al. Among authors: okamoto y. World J Biol Chem. 2010 Oct 26;1(10):298-306. doi: 10.4331/wjbc.v1.i10.298. World J Biol Chem. 2010. PMID: 21537463 Free PMC article.
3,908 results