Chen CY - Search Results

1

Asymmetric Formal Synthesis of the Long-Acting DPP-4 Inhibitor Omarigliptin.

Peng F, Chen Y, Chen CY, Dormer PG, Kassim A, McLaughlin M, Reamer RA, Sherer EC, Song ZJ, Tan L, Tudge MT, Wan B, Chung JYL. Peng F, et al. Among authors: chen cy, chen y. J Org Chem. 2017 Sep 1;82(17):9023-9029. doi: 10.1021/acs.joc.7b01467. Epub 2017 Aug 14. J Org Chem. 2017. PMID: 28776371 Free PMC article.

2

Practical asymmetric synthesis of a potent PDE4 inhibitor via stereoselective enolate alkylation of a chiral aryl-heteroaryl secondary tosylate.

O'Shea PD, Chen CY, Chen W, Dagneau P, Frey LF, Grabowski EJ, Marcantonio KM, Reamer RA, Tan L, Tillyer RD, Roy A, Wang X, Zhao D. O'Shea PD, et al. Among authors: chen cy, chen w. J Org Chem. 2005 Apr 15;70(8):3021-30. doi: 10.1021/jo048156v. J Org Chem. 2005. PMID: 15822960

3

Synthesis of benzo[b]furans via CuI-catalyzed ring closure.

Chen CY, Dormer PG. Chen CY, et al. J Org Chem. 2005 Aug 19;70(17):6964-7. doi: 10.1021/jo050788+. J Org Chem. 2005. PMID: 16095327

4

A mild and efficient synthesis of 4-quinolones and quinolone heterocycles.

Zewge D, Chen CY, Deer C, Dormer PG, Hughes DL. Zewge D, et al. Among authors: chen cy. J Org Chem. 2007 May 25;72(11):4276-9. doi: 10.1021/jo070181o. Epub 2007 Apr 26. J Org Chem. 2007. PMID: 17458997

5

Enantioselective Pd-catalyzed alpha-arylation of N-Boc-pyrrolidine: the key to an efficient and practical synthesis of a glucokinase activator.

Klapars A, Campos KR, Waldman JH, Zewge D, Dormer PG, Chen CY. Klapars A, et al. Among authors: chen cy. J Org Chem. 2008 Jul 4;73(13):4986-93. doi: 10.1021/jo8006804. Epub 2008 May 29. J Org Chem. 2008. PMID: 18507444

6

A general method for the synthesis of 3,5-diarylcyclopentenones via friedel-crafts acylation of vinyl chlorides.

Xu Y, McLaughlin M, Chen CY, Reamer RA, Dormer PG, Davies IW. Xu Y, et al. Among authors: chen cy. J Org Chem. 2009 Jul 17;74(14):5100-3. doi: 10.1021/jo900696k. J Org Chem. 2009. PMID: 19485346

7

Synthesis of α-hydroxyacetophenones.

McLaughlin M, Belyk KM, Qian G, Reamer RA, Chen CY. McLaughlin M, et al. Among authors: chen cy. J Org Chem. 2012 Jun 1;77(11):5144-8. doi: 10.1021/jo3005556. Epub 2012 May 22. J Org Chem. 2012. PMID: 22568765

8

Enantioselective synthesis of an HCV NS5a antagonist.

Mangion IK, Chen CY, Li H, Maligres P, Chen Y, Christensen M, Cohen R, Jeon I, Klapars A, Krska S, Nguyen H, Reamer RA, Sherry BD, Zavialov I. Mangion IK, et al. Among authors: chen cy, chen y. Org Lett. 2014 May 2;16(9):2310-3. doi: 10.1021/ol500971c. Epub 2014 Apr 11. Org Lett. 2014. PMID: 24724971

9

Asymmetric synthesis of cyclic indole aminals via 1,3-stereoinduction.

Li H, Chen CY, Nguyen H, Cohen R, Maligres PE, Yasuda N, Mangion I, Zavialov I, Reibarkh M, Chung JY. Li H, et al. Among authors: chen cy. J Org Chem. 2014 Sep 19;79(18):8533-40. doi: 10.1021/jo501581e. Epub 2014 Sep 3. J Org Chem. 2014. PMID: 25162915

10

Mild and practical method for the alpha-arylation of nitriles with heteroaryl halides.

Klapars A, Waldman JH, Campos KR, Jensen MS, McLaughlin M, Chung JY, Cvetovich RJ, Chen CY. Klapars A, et al. Among authors: chen cy. J Org Chem. 2005 Nov 25;70(24):10186-9. doi: 10.1021/jo051737f. J Org Chem. 2005. PMID: 16292870

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