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Allosteric inhibition of carnosinase (CN1) by inducing a conformational shift.
Peters V, Schmitt CP, Weigand T, Klingbeil K, Thiel C, van den Berg A, Calabrese V, Nawroth P, Fleming T, Forsberg E, Wagner AH, Hecker M, Vistoli G. Peters V, et al. Among authors: forsberg e. J Enzyme Inhib Med Chem. 2017 Dec;32(1):1102-1110. doi: 10.1080/14756366.2017.1355793. J Enzyme Inhib Med Chem. 2017. PMID: 28776438 Free PMC article.
Carnosine metabolism in diabetes is altered by reactive metabolites.
Peters V, Lanthaler B, Amberger A, Fleming T, Forsberg E, Hecker M, Wagner AH, Yue WW, Hoffmann GF, Nawroth P, Zschocke J, Schmitt CP. Peters V, et al. Among authors: forsberg e. Amino Acids. 2015 Nov;47(11):2367-76. doi: 10.1007/s00726-015-2024-z. Epub 2015 Jun 17. Amino Acids. 2015. PMID: 26081982
Protective Actions of Anserine Under Diabetic Conditions.
Peters V, Calabrese V, Forsberg E, Volk N, Fleming T, Baelde H, Weigand T, Thiel C, Trovato A, Scuto M, Modafferi S, Schmitt CP. Peters V, et al. Among authors: forsberg e. Int J Mol Sci. 2018 Sep 13;19(9):2751. doi: 10.3390/ijms19092751. Int J Mol Sci. 2018. PMID: 30217069 Free PMC article.
Repression of hypoxia-inducible factor-1 contributes to increased mitochondrial reactive oxygen species production in diabetes.
Zheng X, Narayanan S, Xu C, Eliasson Angelstig S, Grünler J, Zhao A, Di Toro A, Bernardi L, Mazzone M, Carmeliet P, Del Sole M, Solaini G, Forsberg EA, Zhang A, Brismar K, Schiffer TA, Rajamand Ekberg N, Botusan IR, Palm F, Catrina SB. Zheng X, et al. Elife. 2022 Feb 15;11:e70714. doi: 10.7554/eLife.70714. Elife. 2022. PMID: 35164902 Free PMC article.
240 results