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Allosteric inhibition of carnosinase (CN1) by inducing a conformational shift.
Peters V, Schmitt CP, Weigand T, Klingbeil K, Thiel C, van den Berg A, Calabrese V, Nawroth P, Fleming T, Forsberg E, Wagner AH, Hecker M, Vistoli G. Peters V, et al. Among authors: nawroth p. J Enzyme Inhib Med Chem. 2017 Dec;32(1):1102-1110. doi: 10.1080/14756366.2017.1355793. J Enzyme Inhib Med Chem. 2017. PMID: 28776438 Free PMC article.
Carnosine metabolism in diabetes is altered by reactive metabolites.
Peters V, Lanthaler B, Amberger A, Fleming T, Forsberg E, Hecker M, Wagner AH, Yue WW, Hoffmann GF, Nawroth P, Zschocke J, Schmitt CP. Peters V, et al. Among authors: nawroth p. Amino Acids. 2015 Nov;47(11):2367-76. doi: 10.1007/s00726-015-2024-z. Epub 2015 Jun 17. Amino Acids. 2015. PMID: 26081982
Carnosine Catalyzes the Formation of the Oligo/Polymeric Products of Methylglyoxal.
Weigand T, Singler B, Fleming T, Nawroth P, Klika KD, Thiel C, Baelde H, Garbade SF, Wagner AH, Hecker M, Yard BA, Amberger A, Zschocke J, Schmitt CP, Peters V. Weigand T, et al. Among authors: nawroth p. Cell Physiol Biochem. 2018;46(2):713-726. doi: 10.1159/000488727. Epub 2018 Mar 29. Cell Physiol Biochem. 2018. PMID: 29621776 Free article.
CNDP1 knockout in zebrafish alters the amino acid metabolism, restrains weight gain, but does not protect from diabetic complications.
Schmöhl F, Peters V, Schmitt CP, Poschet G, Büttner M, Li X, Weigand T, Poth T, Volk N, Morgenstern J, Fleming T, Nawroth PP, Kroll J. Schmöhl F, et al. Among authors: nawroth pp. Cell Mol Life Sci. 2019 Nov;76(22):4551-4568. doi: 10.1007/s00018-019-03127-z. Epub 2019 May 9. Cell Mol Life Sci. 2019. PMID: 31073745 Free PMC article.
Clinical Trials on Diabetic Nephropathy: A Cross-Sectional Analysis.
Modafferi S, Ries M, Calabrese V, Schmitt CP, Nawroth P, Kopf S, Peters V. Modafferi S, et al. Among authors: nawroth p. Diabetes Ther. 2019 Feb;10(1):229-243. doi: 10.1007/s13300-018-0551-9. Epub 2019 Jan 7. Diabetes Ther. 2019. PMID: 30617943 Free PMC article.
634 results