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104 results

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Page 1
Erythropoietin signaling regulates heme biosynthesis.
Chung J, Wittig JG, Ghamari A, Maeda M, Dailey TA, Bergonia H, Kafina MD, Coughlin EE, Minogue CE, Hebert AS, Li L, Kaplan J, Lodish HF, Bauer DE, Orkin SH, Cantor AB, Maeda T, Phillips JD, Coon JJ, Pagliarini DJ, Dailey HA, Paw BH. Chung J, et al. Among authors: paw bh. Elife. 2017 May 29;6:e24767. doi: 10.7554/eLife.24767. Elife. 2017. PMID: 28553927 Free PMC article.
FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity.
Yien YY, Shi J, Chen C, Cheung JTM, Grillo AS, Shrestha R, Li L, Zhang X, Kafina MD, Kingsley PD, King MJ, Ablain J, Li H, Zon LI, Palis J, Burke MD, Bauer DE, Orkin SH, Koehler CM, Phillips JD, Kaplan J, Ward DM, Lodish HF, Paw BH. Yien YY, et al. Among authors: paw bh. J Biol Chem. 2018 Dec 21;293(51):19797-19811. doi: 10.1074/jbc.RA118.002742. Epub 2018 Oct 26. J Biol Chem. 2018. PMID: 30366982 Free PMC article.
A recurring mutation in the respiratory complex 1 protein NDUFB11 is responsible for a novel form of X-linked sideroblastic anemia.
Lichtenstein DA, Crispin AW, Sendamarai AK, Campagna DR, Schmitz-Abe K, Sousa CM, Kafina MD, Schmidt PJ, Niemeyer CM, Porter J, May A, Patnaik MM, Heeney MM, Kimmelman A, Bottomley SS, Paw BH, Markianos K, Fleming MD. Lichtenstein DA, et al. Among authors: paw bh. Blood. 2016 Oct 13;128(15):1913-1917. doi: 10.1182/blood-2016-05-719062. Epub 2016 Aug 3. Blood. 2016. PMID: 27488349 Free PMC article.
Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals.
Grillo AS, SantaMaria AM, Kafina MD, Cioffi AG, Huston NC, Han M, Seo YA, Yien YY, Nardone C, Menon AV, Fan J, Svoboda DC, Anderson JB, Hong JD, Nicolau BG, Subedi K, Gewirth AA, Wessling-Resnick M, Kim J, Paw BH, Burke MD. Grillo AS, et al. Among authors: paw bh. Science. 2017 May 12;356(6338):608-616. doi: 10.1126/science.aah3862. Science. 2017. PMID: 28495746 Free PMC article.
Reductions in the mitochondrial ABC transporter Abcb10 affect the transcriptional profile of heme biosynthesis genes.
Seguin A, Takahashi-Makise N, Yien YY, Huston NC, Whitman JC, Musso G, Wallace JA, Bradley T, Bergonia HA, Kafina MD, Matsumoto M, Igarashi K, Phillips JD, Paw BH, Kaplan J, Ward DM. Seguin A, et al. Among authors: paw bh. J Biol Chem. 2017 Sep 29;292(39):16284-16299. doi: 10.1074/jbc.M117.797415. Epub 2017 Aug 14. J Biol Chem. 2017. PMID: 28808058 Free PMC article.
Mutation in human CLPX elevates levels of δ-aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyria.
Yien YY, Ducamp S, van der Vorm LN, Kardon JR, Manceau H, Kannengiesser C, Bergonia HA, Kafina MD, Karim Z, Gouya L, Baker TA, Puy H, Phillips JD, Nicolas G, Paw BH. Yien YY, et al. Among authors: paw bh. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E8045-E8052. doi: 10.1073/pnas.1700632114. Epub 2017 Sep 5. Proc Natl Acad Sci U S A. 2017. PMID: 28874591 Free PMC article.
Heme metabolism and erythropoiesis.
Chung J, Chen C, Paw BH. Chung J, et al. Among authors: paw bh. Curr Opin Hematol. 2012 May;19(3):156-62. doi: 10.1097/MOH.0b013e328351c48b. Curr Opin Hematol. 2012. PMID: 22406824 Free PMC article. Review.
Iron and porphyrin trafficking in heme biogenesis.
Schultz IJ, Chen C, Paw BH, Hamza I. Schultz IJ, et al. Among authors: paw bh. J Biol Chem. 2010 Aug 27;285(35):26753-26759. doi: 10.1074/jbc.R110.119503. Epub 2010 Jun 3. J Biol Chem. 2010. PMID: 20522548 Free PMC article. Review.
104 results