McKenzie GJ - Search Results

1

Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS.

Narvaez AJ, Ber S, Crooks A, Emery A, Hardwick B, Guarino Almeida E, Huggins DJ, Perera D, Roberts-Thomson M, Azzarelli R, Hood FE, Prior IA, Walker DW, Boyce R, Boyle RG, Barker SP, Torrance CJ, McKenzie GJ, Venkitaraman AR. Narvaez AJ, et al. Among authors: mckenzie gj. Cell Chem Biol. 2017 Aug 17;24(8):1017-1028.e7. doi: 10.1016/j.chembiol.2017.07.009. Epub 2017 Aug 10. Cell Chem Biol. 2017. PMID: 28807782 Free PMC article.

2

Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions.

Laraia L, McKenzie G, Spring DR, Venkitaraman AR, Huggins DJ. Laraia L, et al. Chem Biol. 2015 Jun 18;22(6):689-703. doi: 10.1016/j.chembiol.2015.04.019. Chem Biol. 2015. PMID: 26091166 Free PMC article. Review.

3

Computational analysis of phosphopeptide binding to the polo-box domain of the mitotic kinase PLK1 using molecular dynamics simulation.

Huggins DJ, McKenzie GJ, Robinson DD, Narváez AJ, Hardwick B, Roberts-Thomson M, Venkitaraman AR, Grant GH, Payne MC. Huggins DJ, et al. Among authors: mckenzie gj. PLoS Comput Biol. 2010 Aug 12;6(8):e1000880. doi: 10.1371/journal.pcbi.1000880. PLoS Comput Biol. 2010. PMID: 20711360 Free PMC article.

4

A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation.

Sharma P, Mahen R, Rossmann M, Stokes JE, Hardwick B, Huggins DJ, Emery A, Kunciw DL, Hyvönen M, Spring DR, McKenzie GJ, Venkitaraman AR. Sharma P, et al. Among authors: mckenzie gj. Sci Rep. 2019 Nov 4;9(1):15930. doi: 10.1038/s41598-019-50702-2. Sci Rep. 2019. PMID: 31685831 Free PMC article.

5

A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.

Scott DE, Francis-Newton NJ, Marsh ME, Coyne AG, Fischer G, Moschetti T, Bayly AR, Sharpe TD, Haas KT, Barber L, Valenzano CR, Srinivasan R, Huggins DJ, Lee M, Emery A, Hardwick B, Ehebauer M, Dagostin C, Esposito A, Pellegrini L, Perrior T, McKenzie G, Blundell TL, Hyvönen M, Skidmore J, Venkitaraman AR, Abell C. Scott DE, et al. Cell Chem Biol. 2021 Jun 17;28(6):835-847.e5. doi: 10.1016/j.chembiol.2021.02.006. Epub 2021 Mar 3. Cell Chem Biol. 2021. PMID: 33662256 Free PMC article.

6

From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1.

Śledź P, Stubbs CJ, Lang S, Yang YQ, McKenzie GJ, Venkitaraman AR, Hyvönen M, Abell C. Śledź P, et al. Among authors: mckenzie gj. Angew Chem Int Ed Engl. 2011 Apr 18;50(17):4003-6. doi: 10.1002/anie.201008019. Epub 2011 Mar 29. Angew Chem Int Ed Engl. 2011. PMID: 21472932 Free PMC article. No abstract available.

7

Interrogation of the protein-protein interactions between human BRCA2 BRC repeats and RAD51 reveals atomistic determinants of affinity.

Cole DJ, Rajendra E, Roberts-Thomson M, Hardwick B, McKenzie GJ, Payne MC, Venkitaraman AR, Skylaris CK. Cole DJ, et al. Among authors: mckenzie gj. PLoS Comput Biol. 2011 Jul;7(7):e1002096. doi: 10.1371/journal.pcbi.1002096. Epub 2011 Jul 14. PLoS Comput Biol. 2011. PMID: 21789034 Free PMC article.

8

Linear aliphatic dialkynes as alternative linkers for double-click stapling of p53-derived peptides.

Lau YH, de Andrade P, McKenzie GJ, Venkitaraman AR, Spring DR. Lau YH, et al. Among authors: mckenzie gj. Chembiochem. 2014 Dec 15;15(18):2680-3. doi: 10.1002/cbic.201402374. Epub 2014 Oct 29. Chembiochem. 2014. PMID: 25354189

9

Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2.

Janeček M, Rossmann M, Sharma P, Emery A, Huggins DJ, Stockwell SR, Stokes JE, Tan YS, Almeida EG, Hardwick B, Narvaez AJ, Hyvönen M, Spring DR, McKenzie GJ, Venkitaraman AR. Janeček M, et al. Among authors: mckenzie gj. Sci Rep. 2016 Jun 24;6:28528. doi: 10.1038/srep28528. Sci Rep. 2016. PMID: 27339427 Free PMC article.

10

Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction.

Cole DJ, Janecek M, Stokes JE, Rossmann M, Faver JC, McKenzie GJ, Venkitaraman AR, Hyvönen M, Spring DR, Huggins DJ, Jorgensen WL. Cole DJ, et al. Among authors: mckenzie gj. Chem Commun (Camb). 2017 Aug 17;53(67):9372-9375. doi: 10.1039/c7cc05379g. Chem Commun (Camb). 2017. PMID: 28787041 Free PMC article.

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