Gu J - Search Results

1

Uncoupling the Mitogenic and Metabolic Functions of FGF1 by Tuning FGF1-FGF Receptor Dimer Stability.

Huang Z, Tan Y, Gu J, Liu Y, Song L, Niu J, Zhao L, Srinivasan L, Lin Q, Deng J, Li Y, Conklin DJ, Neubert TA, Cai L, Li X, Mohammadi M. Huang Z, et al. Among authors: gu j. Cell Rep. 2017 Aug 15;20(7):1717-1728. doi: 10.1016/j.celrep.2017.06.063. Cell Rep. 2017. PMID: 28813681 Free PMC article.

2

Curtailing FGF19's mitogenicity by suppressing its receptor dimerization ability.

Niu J, Zhao J, Wu J, Qiao G, Gu J, Zhou C, Li Q, Ying L, Wang D, Lin H, Li X, Mohammadi M, Huang Z. Niu J, et al. Among authors: gu j. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):29025-29034. doi: 10.1073/pnas.2010984117. Epub 2020 Nov 3. Proc Natl Acad Sci U S A. 2020. PMID: 33144503 Free PMC article.

3

A new FGF1 variant protects against adriamycin-induced cardiotoxicity via modulating p53 activity.

Xiao M, Tang Y, Wang J (a), Lu G, Niu J, Wang J (b), Li J, Liu Q, Wang Z, Huang Z, Guo Y, Gao T, Zhang X, Yue S, Gu J. Xiao M, et al. Among authors: gu j. Redox Biol. 2022 Feb;49:102219. doi: 10.1016/j.redox.2021.102219. Epub 2021 Dec 18. Redox Biol. 2022. PMID: 34990928 Free PMC article.

4

Fenofibrate increases cardiac autophagy via FGF21/SIRT1 and prevents fibrosis and inflammation in the hearts of Type 1 diabetic mice.

Zhang J, Cheng Y, Gu J, Wang S, Zhou S, Wang Y, Tan Y, Feng W, Fu Y, Mellen N, Cheng R, Ma J, Zhang C, Li Z, Cai L. Zhang J, et al. Among authors: gu j. Clin Sci (Lond). 2016 Apr;130(8):625-41. doi: 10.1042/CS20150623. Epub 2016 Jan 21. Clin Sci (Lond). 2016. PMID: 26795437

5

Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts.

Gu J, Yan X, Dai X, Wang Y, Lin Q, Xiao J, Zhou S, Zhang J, Wang K, Zeng J, Xin Y, Barati MT, Zhang C, Bai Y, Li Y, Epstein PN, Wintergerst KA, Li X, Tan Y, Cai L. Gu J, et al. Diabetes. 2018 Mar;67(3):507-517. doi: 10.2337/db17-0219. Epub 2017 Oct 27. Diabetes. 2018. PMID: 29079702 Free PMC article.

6

Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis.

Gu J, Wang S, Guo H, Tan Y, Liang Y, Feng A, Liu Q, Damodaran C, Zhang Z, Keller BB, Zhang C, Cai L. Gu J, et al. Cell Death Dis. 2018 Jan 23;9(2):82. doi: 10.1038/s41419-017-0093-5. Cell Death Dis. 2018. PMID: 29362483 Free PMC article.

7

Murine double minute 2 siRNA and wild-type p53 gene therapy enhances sensitivity of the SKOV3/DDP ovarian cancer cell line to cisplatin chemotherapy in vitro and in vivo.

Gu J, Tang Y, Liu Y, Guo H, Wang Y, Cai L, Li Y, Wang B. Gu J, et al. Cancer Lett. 2014 Feb 28;343(2):200-9. doi: 10.1016/j.canlet.2013.10.011. Epub 2013 Oct 23. Cancer Lett. 2014. PMID: 24161623

8

HDAC3 inhibition in diabetic mice may activate Nrf2 preventing diabetes-induced liver damage and FGF21 synthesis and secretion leading to aortic protection.

Zhang J, Xu Z, Gu J, Jiang S, Liu Q, Zheng Y, Freedman JH, Sun J, Cai L. Zhang J, et al. Among authors: gu j. Am J Physiol Endocrinol Metab. 2018 Aug 1;315(2):E150-E162. doi: 10.1152/ajpendo.00465.2017. Epub 2018 Apr 10. Am J Physiol Endocrinol Metab. 2018. PMID: 29634312 Free article.

9

Fibroblast growth factor 21 protects the heart from apoptosis in a diabetic mouse model via extracellular signal-regulated kinase 1/2-dependent signalling pathway.

Zhang C, Huang Z, Gu J, Yan X, Lu X, Zhou S, Wang S, Shao M, Zhang F, Cheng P, Feng W, Tan Y, Li X. Zhang C, et al. Among authors: gu j. Diabetologia. 2015 Aug;58(8):1937-48. doi: 10.1007/s00125-015-3630-8. Epub 2015 Jun 4. Diabetologia. 2015. PMID: 26040473

10

C66 ameliorates diabetic nephropathy in mice by both upregulating NRF2 function via increase in miR-200a and inhibiting miR-21.

Wu H, Kong L, Tan Y, Epstein PN, Zeng J, Gu J, Liang G, Kong M, Chen X, Miao L, Cai L. Wu H, et al. Among authors: gu j. Diabetologia. 2016 Jul;59(7):1558-1568. doi: 10.1007/s00125-016-3958-8. Epub 2016 Apr 26. Diabetologia. 2016. PMID: 27115417 Free PMC article.

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