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Page 1
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin.
Greggio E, Jain S, Kingsbury A, Bandopadhyay R, Lewis P, Kaganovich A, van der Brug MP, Beilina A, Blackinton J, Thomas KJ, Ahmad R, Miller DW, Kesavapany S, Singleton A, Lees A, Harvey RJ, Harvey K, Cookson MR. Greggio E, et al. Among authors: cookson mr. Neurobiol Dis. 2006 Aug;23(2):329-41. doi: 10.1016/j.nbd.2006.04.001. Epub 2006 Jun 5. Neurobiol Dis. 2006. PMID: 16750377
The R1441C mutation of LRRK2 disrupts GTP hydrolysis.
Lewis PA, Greggio E, Beilina A, Jain S, Baker A, Cookson MR. Lewis PA, et al. Among authors: cookson mr. Biochem Biophys Res Commun. 2007 Jun 8;357(3):668-71. doi: 10.1016/j.bbrc.2007.04.006. Epub 2007 Apr 10. Biochem Biophys Res Commun. 2007. PMID: 17442267 Free PMC article.
The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation.
Greggio E, Zambrano I, Kaganovich A, Beilina A, Taymans JM, Daniëls V, Lewis P, Jain S, Ding J, Syed A, Thomas KJ, Baekelandt V, Cookson MR. Greggio E, et al. Among authors: cookson mr. J Biol Chem. 2008 Jun 13;283(24):16906-14. doi: 10.1074/jbc.M708718200. Epub 2008 Apr 8. J Biol Chem. 2008. PMID: 18397888 Free PMC article.
The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites.
Greggio E, Taymans JM, Zhen EY, Ryder J, Vancraenenbroeck R, Beilina A, Sun P, Deng J, Jaffe H, Baekelandt V, Merchant K, Cookson MR. Greggio E, et al. Among authors: cookson mr. Biochem Biophys Res Commun. 2009 Nov 20;389(3):449-54. doi: 10.1016/j.bbrc.2009.08.163. Epub 2009 Sep 3. Biochem Biophys Res Commun. 2009. PMID: 19733152 Free PMC article.
14-3-3 proteins are promising LRRK2 interactors.
Rudenko IN, Cookson MR. Rudenko IN, et al. Among authors: cookson mr. Biochem J. 2010 Sep 15;430(3):e5-6. doi: 10.1042/BJ20101200. Biochem J. 2010. PMID: 20795948
Role of LRRK2 kinase dysfunction in Parkinson disease.
Kumar A, Cookson MR. Kumar A, et al. Among authors: cookson mr. Expert Rev Mol Med. 2011 Jun 13;13:e20. doi: 10.1017/S146239941100192X. Expert Rev Mol Med. 2011. PMID: 21676337 Free PMC article. Review.
Cellular effects of LRRK2 mutations.
Cookson MR. Cookson MR. Biochem Soc Trans. 2012 Oct;40(5):1070-3. doi: 10.1042/BST20120165. Biochem Soc Trans. 2012. PMID: 22988867 Free PMC article. Review.
347 results