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Potentiators exert distinct effects on human, murine, and Xenopus CFTR.
Cui G, Khazanov N, Stauffer BB, Infield DT, Imhoff BR, Senderowitz H, McCarty NA. Cui G, et al. Among authors: khazanov n. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L192-207. doi: 10.1152/ajplung.00056.2016. Epub 2016 Jun 10. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 27288484 Free PMC article.
Specific stabilization of CFTR by phosphatidylserine.
Hildebrandt E, Khazanov N, Kappes JC, Dai Q, Senderowitz H, Urbatsch IL. Hildebrandt E, et al. Among authors: khazanov n. Biochim Biophys Acta Biomembr. 2017 Feb;1859(2):289-293. doi: 10.1016/j.bbamem.2016.11.013. Epub 2016 Nov 30. Biochim Biophys Acta Biomembr. 2017. PMID: 27913277 Free PMC article.
Structural stability of purified human CFTR is systematically improved by mutations in nucleotide binding domain 1.
Yang Z, Hildebrandt E, Jiang F, Aleksandrov AA, Khazanov N, Zhou Q, An J, Mezzell AT, Xavier BM, Ding H, Riordan JR, Senderowitz H, Kappes JC, Brouillette CG, Urbatsch IL. Yang Z, et al. Among authors: khazanov n. Biochim Biophys Acta Biomembr. 2018 May;1860(5):1193-1204. doi: 10.1016/j.bbamem.2018.02.006. Epub 2018 Feb 7. Biochim Biophys Acta Biomembr. 2018. PMID: 29425673 Free PMC article.
Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator.
Wang C, Aleksandrov AA, Yang Z, Forouhar F, Proctor EA, Kota P, An J, Kaplan A, Khazanov N, Boël G, Stockwell BR, Senderowitz H, Dokholyan NV, Riordan JR, Brouillette CG, Hunt JF. Wang C, et al. Among authors: khazanov n. J Biol Chem. 2018 Nov 16;293(46):17685-17704. doi: 10.1074/jbc.RA117.000819. Epub 2018 Jun 14. J Biol Chem. 2018. PMID: 29903914 Free PMC article.
The Q359K/T360K mutation causes cystic fibrosis in Georgian Jews.
Mei-Zahav M, Stafler P, Senderowitz H, Bentur L, Livnat G, Shteinberg M, Orenstein N, Bazak L, Prais D, Levine H, Gur M, Khazanov N, Simhaev L, Eliyahu H, Cohen M, Wilschanski M, Blau H, Mussaffi H. Mei-Zahav M, et al. Among authors: khazanov n. J Cyst Fibros. 2018 Sep;17(5):e41-e45. doi: 10.1016/j.jcf.2018.06.008. Epub 2018 Jul 20. J Cyst Fibros. 2018. PMID: 30033373 Free article.
Guaiacol as a drug candidate for treating adult polyglucosan body disease.
Kakhlon O, Ferreira I, Solmesky LJ, Khazanov N, Lossos A, Alvarez R, Yetil D, Pampou S, Weil M, Senderowitz H, Escriba P, Yue WW, Akman HO. Kakhlon O, et al. Among authors: khazanov n. JCI Insight. 2018 Sep 6;3(17):e99694. doi: 10.1172/jci.insight.99694. eCollection 2018 Sep 6. JCI Insight. 2018. PMID: 30185673 Free PMC article.
43 results