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Page 1
MSA prions exhibit remarkable stability and resistance to inactivation.
Woerman AL, Kazmi SA, Patel S, Freyman Y, Oehler A, Aoyagi A, Mordes DA, Halliday GM, Middleton LT, Gentleman SM, Olson SH, Prusiner SB. Woerman AL, et al. Among authors: aoyagi a. Acta Neuropathol. 2018 Jan;135(1):49-63. doi: 10.1007/s00401-017-1762-2. Epub 2017 Aug 28. Acta Neuropathol. 2018. PMID: 28849371 Free PMC article.
Propagation of prions causing synucleinopathies in cultured cells.
Woerman AL, Stöhr J, Aoyagi A, Rampersaud R, Krejciova Z, Watts JC, Ohyama T, Patel S, Widjaja K, Oehler A, Sanders DW, Diamond MI, Seeley WW, Middleton LT, Gentleman SM, Mordes DA, Südhof TC, Giles K, Prusiner SB. Woerman AL, et al. Among authors: aoyagi a. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4949-58. doi: 10.1073/pnas.1513426112. Epub 2015 Aug 18. Proc Natl Acad Sci U S A. 2015. PMID: 26286986 Free PMC article.
α-Synuclein: Multiple System Atrophy Prions.
Woerman AL, Watts JC, Aoyagi A, Giles K, Middleton LT, Prusiner SB. Woerman AL, et al. Among authors: aoyagi a. Cold Spring Harb Perspect Med. 2018 Jul 2;8(7):a024588. doi: 10.1101/cshperspect.a024588. Cold Spring Harb Perspect Med. 2018. PMID: 28213437 Free PMC article. Review.
Discovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity.
Grandjean JM, Jiu AY, West JW, Aoyagi A, Droege DG, Elepano M, Hirasawa M, Hirouchi M, Murakami R, Lee J, Sasaki K, Hirano S, Ohyama T, Tang BC, Vaz RJ, Inoue M, Olson SH, Prusiner SB, Conrad J, Paras NA. Grandjean JM, et al. Among authors: aoyagi a. ACS Med Chem Lett. 2020 Jan 30;11(2):127-132. doi: 10.1021/acsmedchemlett.9b00480. eCollection 2020 Feb 13. ACS Med Chem Lett. 2020. PMID: 32071678 Free PMC article.
Aβ and tau prions feature in the neuropathogenesis of Down syndrome.
Condello C, Maxwell AM, Castillo E, Aoyagi A, Graff C, Ingelsson M, Lannfelt L, Bird TD, Keene CD, Seeley WW, Perl DP, Head E, Prusiner SB. Condello C, et al. Among authors: aoyagi a. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2212954119. doi: 10.1073/pnas.2212954119. Epub 2022 Nov 7. Proc Natl Acad Sci U S A. 2022. PMID: 36343257 Free PMC article.
Aβ and Tau Prions Causing Alzheimer's Disease.
Condello C, Merz GE, Aoyagi A, DeGrado WF, Prusiner SB. Condello C, et al. Among authors: aoyagi a. Methods Mol Biol. 2023;2561:293-337. doi: 10.1007/978-1-0716-2655-9_16. Methods Mol Biol. 2023. PMID: 36399277
Design, synthesis and structure-activity relationships of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease.
Toda N, Tago K, Marumoto S, Takami K, Ori M, Yamada N, Koyama K, Naruto S, Abe K, Yamazaki R, Hara T, Aoyagi A, Abe Y, Kaneko T, Kogen H. Toda N, et al. Among authors: aoyagi a. Bioorg Med Chem. 2003 May 1;11(9):1935-55. doi: 10.1016/s0968-0896(03)00091-9. Bioorg Med Chem. 2003. PMID: 12670645
78 results