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Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time.
Chia S, Low JL, Zhang X, Kwang XL, Chong FT, Sharma A, Bertrand D, Toh SY, Leong HS, Thangavelu MT, Hwang JSG, Lim KH, Skanthakumar T, Tan HK, Su Y, Hui Choo S, Hentze H, Tan IBH, Lezhava A, Tan P, Tan DSW, Periyasamy G, Koh JLY, Gopalakrishna Iyer N, DasGupta R. Chia S, et al. Among authors: leong hs. Nat Commun. 2017 Sep 5;8(1):435. doi: 10.1038/s41467-017-00451-5. Nat Commun. 2017. PMID: 28874669 Free PMC article.
Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance.
Vettore AL, Ramnarayanan K, Poore G, Lim K, Ong CK, Huang KK, Leong HS, Chong FT, Lim TK, Lim WK, Cutcutache I, Mcpherson JR, Suzuki Y, Zhang S, Skanthakumar T, Wang W, Tan DS, Cho BC, Teh BT, Rozen S, Tan P, Iyer NG. Vettore AL, et al. Among authors: leong hs. Genome Med. 2015 Sep 23;7(1):98. doi: 10.1186/s13073-015-0219-2. Genome Med. 2015. PMID: 26395002 Free PMC article.
Vasculogenic mimicry in small cell lung cancer.
Williamson SC, Metcalf RL, Trapani F, Mohan S, Antonello J, Abbott B, Leong HS, Chester CP, Simms N, Polanski R, Nonaka D, Priest L, Fusi A, Carlsson F, Carlsson A, Hendrix MJ, Seftor RE, Seftor EA, Rothwell DG, Hughes A, Hicks J, Miller C, Kuhn P, Brady G, Simpson KL, Blackhall FH, Dive C. Williamson SC, et al. Among authors: leong hs. Nat Commun. 2016 Nov 9;7:13322. doi: 10.1038/ncomms13322. Nat Commun. 2016. PMID: 27827359 Free PMC article.
Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma.
Tan DSW, Chong FT, Leong HS, Toh SY, Lau DP, Kwang XL, Zhang X, Sundaram GM, Tan GS, Chang MM, Chua BT, Lim WT, Tan EH, Ang MK, Lim TKH, Sampath P, Chowbay B, Skanderup AJ, DasGupta R, Iyer NG. Tan DSW, et al. Among authors: leong hs. Nat Med. 2017 Oct;23(10):1167-1175. doi: 10.1038/nm.4401. Epub 2017 Sep 18. Nat Med. 2017. PMID: 28920960
GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers.
Rasheed SAK, Leong HS, Lakshmanan M, Raju A, Dadlani D, Chong FT, Shannon NB, Rajarethinam R, Skanthakumar T, Tan EY, Hwang JSG, Lim KH, Tan DS, Ceppi P, Wang M, Tergaonkar V, Casey PJ, Iyer NG. Rasheed SAK, et al. Among authors: leong hs. Oncogene. 2018 Mar;37(10):1340-1353. doi: 10.1038/s41388-017-0038-6. Epub 2017 Dec 19. Oncogene. 2018. PMID: 29255247 Free PMC article.
Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy.
Sharma A, Cao EY, Kumar V, Zhang X, Leong HS, Wong AML, Ramakrishnan N, Hakimullah M, Teo HMV, Chong FT, Chia S, Thangavelu MT, Kwang XL, Gupta R, Clark JR, Periyasamy G, Iyer NG, DasGupta R. Sharma A, et al. Among authors: leong hs. Nat Commun. 2018 Nov 22;9(1):4931. doi: 10.1038/s41467-018-07261-3. Nat Commun. 2018. PMID: 30467425 Free PMC article.
147 results