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The anti-ErbB2 antibody H2-18 and the pan-PI3K inhibitor GDC-0941 effectively inhibit trastuzumab-resistant ErbB2-overexpressing breast cancer.
Wang L, Yu X, Wang C, Pan S, Liang B, Zhang Y, Chong X, Meng Y, Dong J, Zhao Y, Yang Y, Wang H, Gao J, Wei H, Zhao J, Wang H, Hu C, Xiao W, Li B. Wang L, et al. Among authors: zhang y. Oncotarget. 2017 May 16;8(32):52877-52888. doi: 10.18632/oncotarget.17907. eCollection 2017 Aug 8. Oncotarget. 2017. PMID: 28881779 Free PMC article.
An anti-ErbB2 fully human antibody circumvents trastuzumab resistance.
Lu Q, Wang L, Zhang Y, Yu X, Wang C, Wang H, Yang Y, Chong X, Xia T, Meng Y, Wang Y, Lu C, Zhou L, Li B. Lu Q, et al. Among authors: zhang y. Oncotarget. 2016 Oct 11;7(41):67129-67141. doi: 10.18632/oncotarget.11562. Oncotarget. 2016. PMID: 27564098 Free PMC article.
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