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Synthesis of a muscarinic receptor antagonist via a diastereoselective Michael reaction, selective deoxyfluorination and aromatic metal-halogen exchange reaction.
Mase T, Houpis IN, Akao A, Dorziotis I, Emerson K, Hoang T, Iida T, Itoh T, Kamei K, Kato S, Kato Y, Kawasaki M, Lang F, Lee J, Lynch J, Maligres P, Molina A, Nemoto T, Okada S, Reamer R, Song JZ, Tschaen D, Wada T, Zewge D, Volante RP, Reider PJ, Tomimoto K. Mase T, et al. Among authors: zewge d. J Org Chem. 2001 Oct 5;66(20):6775-86. doi: 10.1021/jo0157425. J Org Chem. 2001. PMID: 11578234
An efficient asymmetric synthesis of an estrogen receptor modulator by sulfoxide-directed borane reduction.
Song ZJ, King AO, Waters MS, Lang F, Zewge D, Bio M, Leazer JL Jr, Javadi G, Kassim A, Tschaen DM, Reamer RA, Rosner T, Chilenski JR, Mathre DJ, Volante RP, Tillyer R. Song ZJ, et al. Among authors: zewge d. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5776-81. doi: 10.1073/pnas.0307415101. Epub 2004 Apr 12. Proc Natl Acad Sci U S A. 2004. PMID: 15079059 Free PMC article.
17 results