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Conformational dynamics of the TTD-PHD histone reader module of the UHRF1 epigenetic regulator reveals multiple histone-binding states, allosteric regulation, and druggability.
Houliston RS, Lemak A, Iqbal A, Ivanochko D, Duan S, Kaustov L, Ong MS, Fan L, Senisterra G, Brown PJ, Wang YX, Arrowsmith CH. Houliston RS, et al. Among authors: fan l. J Biol Chem. 2017 Dec 22;292(51):20947-20959. doi: 10.1074/jbc.M117.799700. Epub 2017 Oct 26. J Biol Chem. 2017. PMID: 29074623 Free PMC article.
Structural basis of peptidoglycan endopeptidase regulation.
Shin JH, Sulpizio AG, Kelley A, Alvarez L, Murphy SG, Fan L, Cava F, Mao Y, Saper MA, Dörr T. Shin JH, et al. Among authors: fan l. Proc Natl Acad Sci U S A. 2020 May 26;117(21):11692-11702. doi: 10.1073/pnas.2001661117. Epub 2020 May 11. Proc Natl Acad Sci U S A. 2020. PMID: 32393643 Free PMC article.
Design and characterization of mutant and wildtype huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems.
Harding RJ, Loppnau P, Ackloo S, Lemak A, Hutchinson A, Hunt B, Holehouse AS, Ho JC, Fan L, Toledo-Sherman L, Seitova A, Arrowsmith CH. Harding RJ, et al. Among authors: fan l. J Biol Chem. 2019 Apr 26;294(17):6986-7001. doi: 10.1074/jbc.RA118.007204. Epub 2019 Mar 6. J Biol Chem. 2019. PMID: 30842263 Free PMC article.
Visualizing RNA conformational and architectural heterogeneity in solution.
Ding J, Lee YT, Bhandari Y, Schwieters CD, Fan L, Yu P, Tarosov SG, Stagno JR, Ma B, Nussinov R, Rein A, Zhang J, Wang YX. Ding J, et al. Among authors: fan l. Nat Commun. 2023 Feb 9;14(1):714. doi: 10.1038/s41467-023-36184-x. Nat Commun. 2023. PMID: 36759615 Free PMC article.
10,161 results
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