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Page 1
NAD+ in Aging: Molecular Mechanisms and Translational Implications.
Fang EF, Lautrup S, Hou Y, Demarest TG, Croteau DL, Mattson MP, Bohr VA. Fang EF, et al. Among authors: mattson mp. Trends Mol Med. 2017 Oct;23(10):899-916. doi: 10.1016/j.molmed.2017.08.001. Epub 2017 Sep 9. Trends Mol Med. 2017. PMID: 28899755 Free PMC article. Review.
A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.
Scheibye-Knudsen M, Mitchell SJ, Fang EF, Iyama T, Ward T, Wang J, Dunn CA, Singh N, Veith S, Hasan-Olive MM, Mangerich A, Wilson MA, Mattson MP, Bergersen LH, Cogger VC, Warren A, Le Couteur DG, Moaddel R, Wilson DM 3rd, Croteau DL, de Cabo R, Bohr VA. Scheibye-Knudsen M, et al. Among authors: mattson mp. Cell Metab. 2014 Nov 4;20(5):840-855. doi: 10.1016/j.cmet.2014.10.005. Epub 2014 Nov 4. Cell Metab. 2014. PMID: 25440059 Free PMC article.
Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms.
Kerr JS, Adriaanse BA, Greig NH, Mattson MP, Cader MZ, Bohr VA, Fang EF. Kerr JS, et al. Among authors: mattson mp. Trends Neurosci. 2017 Mar;40(3):151-166. doi: 10.1016/j.tins.2017.01.002. Epub 2017 Feb 9. Trends Neurosci. 2017. PMID: 28190529 Free PMC article. Review.
NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome.
Fang EF, Hou Y, Lautrup S, Jensen MB, Yang B, SenGupta T, Caponio D, Khezri R, Demarest TG, Aman Y, Figueroa D, Morevati M, Lee HJ, Kato H, Kassahun H, Lee JH, Filippelli D, Okur MN, Mangerich A, Croteau DL, Maezawa Y, Lyssiotis CA, Tao J, Yokote K, Rusten TE, Mattson MP, Jasper H, Nilsen H, Bohr VA. Fang EF, et al. Among authors: mattson mp. Nat Commun. 2019 Nov 21;10(1):5284. doi: 10.1038/s41467-019-13172-8. Nat Commun. 2019. PMID: 31754102 Free PMC article.
NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.
Hou Y, Lautrup S, Cordonnier S, Wang Y, Croteau DL, Zavala E, Zhang Y, Moritoh K, O'Connell JF, Baptiste BA, Stevnsner TV, Mattson MP, Bohr VA. Hou Y, et al. Among authors: mattson mp. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1876-E1885. doi: 10.1073/pnas.1718819115. Epub 2018 Feb 5. Proc Natl Acad Sci U S A. 2018. PMID: 29432159 Free PMC article.
NAD+ in Brain Aging and Neurodegenerative Disorders.
Lautrup S, Sinclair DA, Mattson MP, Fang EF. Lautrup S, et al. Among authors: mattson mp. Cell Metab. 2019 Oct 1;30(4):630-655. doi: 10.1016/j.cmet.2019.09.001. Cell Metab. 2019. PMID: 31577933 Free PMC article. Review.
Mitochondrial DNA damage and repair in neurodegenerative disorders.
Yang JL, Weissman L, Bohr VA, Mattson MP. Yang JL, et al. Among authors: mattson mp. DNA Repair (Amst). 2008 Jul 1;7(7):1110-20. doi: 10.1016/j.dnarep.2008.03.012. Epub 2008 May 7. DNA Repair (Amst). 2008. PMID: 18463003 Free PMC article. Review.
Loss of NEIL1 causes defects in olfactory function in mice.
Canugovi C, Misiak M, Scheibye-Knudsen M, Croteau DL, Mattson MP, Bohr VA. Canugovi C, et al. Among authors: mattson mp. Neurobiol Aging. 2015 Feb;36(2):1007-12. doi: 10.1016/j.neurobiolaging.2014.09.026. Epub 2014 Oct 14. Neurobiol Aging. 2015. PMID: 25448603 Free PMC article.
DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes.
Sykora P, Misiak M, Wang Y, Ghosh S, Leandro GS, Liu D, Tian J, Baptiste BA, Cong WN, Brenerman BM, Fang E, Becker KG, Hamilton RJ, Chigurupati S, Zhang Y, Egan JM, Croteau DL, Wilson DM 3rd, Mattson MP, Bohr VA. Sykora P, et al. Among authors: mattson mp. Nucleic Acids Res. 2015 Jan;43(2):943-59. doi: 10.1093/nar/gku1356. Epub 2014 Dec 30. Nucleic Acids Res. 2015. PMID: 25552414 Free PMC article.
986 results