de Villiers M - Search Results

1

Acetyl-4'-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency.

Di Meo I, Colombelli C, Srinivasan B, de Villiers M, Hamada J, Jeong SY, Fox R, Woltjer RL, Tepper PG, Lahaye LL, Rizzetto E, Harrs CH, de Boer T, van der Zwaag M, Jenko B, Čusak A, Pahor J, Kosec G, Grzeschik NA, Hayflick SJ, Tiranti V, Sibon OCM. Di Meo I, et al. Among authors: de villiers m, de boer t. Sci Rep. 2017 Sep 12;7(1):11260. doi: 10.1038/s41598-017-11564-8. Sci Rep. 2017. PMID: 28900161 Free PMC article.

2

Antiplasmodial Mode of Action of Pantothenamides: Pantothenate Kinase Serves as a Metabolic Activator Not as a Target.

de Villiers M, Spry C, Macuamule CJ, Barnard L, Wells G, Saliba KJ, Strauss E. de Villiers M, et al. ACS Infect Dis. 2017 Jul 14;3(7):527-541. doi: 10.1021/acsinfecdis.7b00024. Epub 2017 May 4. ACS Infect Dis. 2017. PMID: 28437604

3

Variation in pantothenate kinase type determines the pantothenamide mode of action and impacts on coenzyme A salvage biosynthesis.

de Villiers M, Barnard L, Koekemoer L, Snoep JL, Strauss E. de Villiers M, et al. FEBS J. 2014 Oct;281(20):4731-53. doi: 10.1111/febs.13013. Epub 2014 Oct 7. FEBS J. 2014. PMID: 25156889 Free article.

4

Metabolism: Jump-starting CoA biosynthesis.

de Villiers M, Strauss E. de Villiers M, et al. Nat Chem Biol. 2015 Oct;11(10):757-8. doi: 10.1038/nchembio.1912. Nat Chem Biol. 2015. PMID: 26379022 No abstract available.

5

Toward a Stable and Potent Coenzyme A-Targeting Antiplasmodial Agent: Structure-Activity Relationship Studies of N-Phenethyl-α-methyl-pantothenamide.

Spry C, Barnard L, Kok M, Powell AK, Mahesh D, Tjhin ET, Saliba KJ, Strauss E, de Villiers M. Spry C, et al. Among authors: de villiers m. ACS Infect Dis. 2020 Jul 10;6(7):1844-1854. doi: 10.1021/acsinfecdis.0c00075. Epub 2020 May 28. ACS Infect Dis. 2020. PMID: 32375471

6

Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development.

Moolman WJ, de Villiers M, Strauss E. Moolman WJ, et al. Among authors: de villiers m. Biochem Soc Trans. 2014 Aug;42(4):1080-6. doi: 10.1042/BST20140131. Biochem Soc Trans. 2014. PMID: 25110006 Review.

7

A pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activity.

Macuamule CJ, Tjhin ET, Jana CE, Barnard L, Koekemoer L, de Villiers M, Saliba KJ, Strauss E. Macuamule CJ, et al. Among authors: de villiers m. Antimicrob Agents Chemother. 2015;59(6):3666-8. doi: 10.1128/AAC.04970-14. Epub 2015 Apr 6. Antimicrob Agents Chemother. 2015. PMID: 25845876 Free PMC article.

8

Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activity.

de Villiers M, Macuamule C, Spry C, Hyun YM, Strauss E, Saliba KJ. de Villiers M, et al. ACS Med Chem Lett. 2013 Jun 17;4(8):784-9. doi: 10.1021/ml400180d. eCollection 2013 Aug 8. ACS Med Chem Lett. 2013. PMID: 24900746 Free PMC article.

9

Adsorption to the Surface of Hemozoin Crystals: Structure-Based Design and Synthesis of Amino-Phenoxazine β-Hematin Inhibitors.

Olivier T, Loots L, Kok M, de Villiers M, Reader J, Birkholtz LM, Arnott GE, de Villiers KA. Olivier T, et al. Among authors: de villiers m, de villiers ka. ChemMedChem. 2022 May 18;17(10):e202200139. doi: 10.1002/cmdc.202200139. Epub 2022 Apr 26. ChemMedChem. 2022. PMID: 35385211 Free PMC article.

10

Inhibitors of the Plasmodium falciparum Hsp90 towards Selective Antimalarial Drug Design: The Past, Present and Future.

Stofberg ML, Caillet C, de Villiers M, Zininga T. Stofberg ML, et al. Among authors: de villiers m. Cells. 2021 Oct 22;10(11):2849. doi: 10.3390/cells10112849. Cells. 2021. PMID: 34831072 Free PMC article. Review.

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