He H - Search Results

1

Physiologically Based Pharmacokinetic Model Predictions of Panobinostat (LBH589) as a Victim and Perpetrator of Drug-Drug Interactions.

Einolf HJ, Lin W, Won CS, Wang L, Gu H, Chun DY, He H, Mangold JB. Einolf HJ, et al. Among authors: he h. Drug Metab Dispos. 2017 Dec;45(12):1304-1316. doi: 10.1124/dmd.117.076851. Epub 2017 Sep 14. Drug Metab Dispos. 2017. PMID: 28912253

2

Absorption, metabolism, and excretion of [14C]vildagliptin, a novel dipeptidyl peptidase 4 inhibitor, in humans.

He H, Tran P, Yin H, Smith H, Batard Y, Wang L, Einolf H, Gu H, Mangold JB, Fischer V, Howard D. He H, et al. Drug Metab Dispos. 2009 Mar;37(3):536-44. doi: 10.1124/dmd.108.023010. Epub 2008 Dec 15. Drug Metab Dispos. 2009. PMID: 19074975

3

Physiologically based pharmacokinetic modeling for assessing the clinical drug-drug interaction of alisporivir.

Xia B, Barve A, Heimbach T, Zhang T, Gu H, Wang L, Einolf H, Alexander N, Hanna I, Ke J, Mangold JB, He H, Sunkara G. Xia B, et al. Among authors: he h. Eur J Pharm Sci. 2014 Oct 15;63:103-12. doi: 10.1016/j.ejps.2014.06.021. Epub 2014 Jul 4. Eur J Pharm Sci. 2014. PMID: 25008118

4

Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans.

Huskey SE, Zhu CQ, Lin MM, Forseth RR, Gu H, Simon O, Eggimann FK, Kittelmann M, Luneau A, Vargas A, Li H, Wang L, Einolf HJ, Zhang J, Favara S, He H, Mangold JB. Huskey SE, et al. Among authors: he h. Drug Metab Dispos. 2016 May;44(5):653-64. doi: 10.1124/dmd.115.069112. Epub 2016 Feb 26. Drug Metab Dispos. 2016. PMID: 26921386

5

Simultaneous Physiologically Based Pharmacokinetic (PBPK) Modeling of Parent and Active Metabolites to Investigate Complex CYP3A4 Drug-Drug Interaction Potential: A Case Example of Midostaurin.

Gu H, Dutreix C, Rebello S, Ouatas T, Wang L, Chun DY, Einolf HJ, He H. Gu H, et al. Among authors: he h. Drug Metab Dispos. 2018 Feb;46(2):109-121. doi: 10.1124/dmd.117.078006. Epub 2017 Nov 8. Drug Metab Dispos. 2018. PMID: 29117990

6

Verification of a physiologically based pharmacokinetic model of ritonavir to estimate drug-drug interaction potential of CYP3A4 substrates.

Umehara KI, Huth F, Won CS, Heimbach T, He H. Umehara KI, et al. Among authors: he h. Biopharm Drug Dispos. 2018 Mar;39(3):152-163. doi: 10.1002/bdd.2122. Biopharm Drug Dispos. 2018. PMID: 29451681

7

Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4-Humanized Mouse Studies With PBPK Modeling.

Zhang J, Heimbach T, Scheer N, Barve A, Li W, Lin W, He H. Zhang J, et al. Among authors: he h. J Pharm Sci. 2016 Apr;105(4):1398-404. doi: 10.1016/j.xphs.2016.01.021. J Pharm Sci. 2016. PMID: 27019957

8

Utilization of Stable Isotope Labeling to Facilitate the Identification of Polar Metabolites of KAF156, an Antimalarial Agent.

Huskey SE, Forseth RR, Li H, Jian Z, Catoire A, Zhang J, Ray T, He H, Flarakos J, Mangold JB. Huskey SE, et al. Among authors: he h. Drug Metab Dispos. 2016 Oct;44(10):1697-708. doi: 10.1124/dmd.116.072108. Epub 2016 Aug 2. Drug Metab Dispos. 2016. PMID: 27486238

9

A Physiologically Based Pharmacokinetic Model to Describe Artemether Pharmacokinetics in Adult and Pediatric Patients.

Lin W, Heimbach T, Jain JP, Awasthi R, Hamed K, Sunkara G, He H. Lin W, et al. Among authors: he h. J Pharm Sci. 2016 Oct;105(10):3205-3213. doi: 10.1016/j.xphs.2016.06.026. Epub 2016 Aug 6. J Pharm Sci. 2016. PMID: 27506269 Free article.

10

Evaluation of Drug-Drug Interaction Potential Between Sacubitril/Valsartan (LCZ696) and Statins Using a Physiologically Based Pharmacokinetic Model.

Lin W, Ji T, Einolf H, Ayalasomayajula S, Lin TH, Hanna I, Heimbach T, Breen C, Jarugula V, He H. Lin W, et al. Among authors: he h. J Pharm Sci. 2017 May;106(5):1439-1451. doi: 10.1016/j.xphs.2017.01.007. Epub 2017 Jan 13. J Pharm Sci. 2017. PMID: 28089685

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